化合物问答
伏拉塞替(CAS号：755038-65-4)通常如何合成？
答案
![N-{trans-4-[4-(Cyclopropylmethyl)-1-piperazinyl]cyclohexyl}-4-{[(7R)-7-ethyl-8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydro-2-pteridinyl]amino}-3-methoxybenzamide](https://cnstatic.chemtradehub.com/structs/755/755038-65-4-5c08.webp "N-{trans-4-[4-(Cyclopropylmethyl)-1-piperazinyl]cyclohexyl}-4-{[(7R)-7-ethyl-8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydro-2-pteridinyl]amino}-3-methoxybenzamide")
伏拉塞替可通过多步反应合成，通常包括环合、酰胺化、芳基化等步骤。首先通过环合反应得到环状化合物，然后通过酰胺化反应引入酰胺基团。最后通过芳基化反应引入苯环结构。具体合成方法和路线可能因文献而异，但通常需要催化剂和保护剂，反应产率约为80%-90%。
关于
CAS号
755038-65-4
英文名称
N-{trans-4-[4-(Cyclopropylmethyl)-1-piperazinyl]cyclohexyl}-4-{[(7R)-7-ethyl-8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydro-2-pteridinyl]amino}-3-methoxybenzamide
中文名称
伏拉塞替
分子式
C34H50N8O3
分子量
618.83 g/mol
SMILES
CCC1C(=O)N(C2=CN=C(N=C2N1C(C)C)NC3=C(C=C(C=C3)C(=O)NC4CCC(CC4)N5CCN(CC5)CC6CC6)OC)C
InChIKey
SXNJFOWDRLKDSF-STROYTFGSA-N
最后更新: 2025-10-07 19:42
![N-{trans-4-[4-(Cyclopropylmethyl)-1-piperazinyl]cyclohexyl}-4-{[(7R)-7-ethyl-8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydro-2-pteridinyl]amino}-3-methoxybenzamide — MedChemExpress LLC](https://cnstatic.chemtradehub.com/suppliers/67ced0fb2b2de6e8e95a67fd/67ced0fb2b2de6e8e95a67fd-logo.webp){kind=logo}
![N-{trans-4-[4-(Cyclopropylmethyl)-1-piperazinyl]cyclohexyl}-4-{[(7R)-7-ethyl-8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydro-2-pteridinyl]amino}-3-methoxybenzamide — 上海赛可锐生物科技有限公司](https://cnstatic.chemtradehub.com/suppliers/67ce67a62b2de6e8e95a4528/67ce67a62b2de6e8e95a4528-logo.webp){kind=logo}
![N-{trans-4-[4-(Cyclopropylmethyl)-1-piperazinyl]cyclohexyl}-4-{[(7R)-7-ethyl-8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydro-2-pteridinyl]amino}-3-methoxybenzamide — 上海创赛科技有限公司](https://cnstatic.chemtradehub.com/suppliers/67cecce82b2de6e8e95a5e02/67cecce82b2de6e8e95a5e02-logo.webp){kind=logo}