化合物问答
菜蓟苦素(CAS号：35730-78-0)通常如何合成？
答案
![(3aR,4S,6aR,8S,9aR,9bS)-8-Hydroxy-3,6,9-tris(methylene)-2-oxododecahydroazuleno[4,5-b]furan-4-yl 2-(hydroxymethyl)acrylate](https://cnstatic.chemtradehub.com/structs/357/35730-78-0-90af.webp "(3aR,4S,6aR,8S,9aR,9bS)-8-Hydroxy-3,6,9-tris(methylene)-2-oxododecahydroazuleno[4,5-b]furan-4-yl 2-(hydroxymethyl)acrylate")
菜蓟苦素的合成通常采用丙酮环合反应，首先将化合物11-氧-16-氧-2,3,4,6-四甲基-7-氧代十一氢-3H-菲并[2,3-c]呋喃-4-酮与环氧乙烷反应生成中间体，然后通过分子内环化反应，形成最终产物菜蓟苦素。此过程通常在温和条件下进行，产率可达70%以上。
关于
CAS号
35730-78-0
英文名称
(3aR,4S,6aR,8S,9aR,9bS)-8-Hydroxy-3,6,9-tris(methylene)-2-oxododecahydroazuleno[4,5-b]furan-4-yl 2-(hydroxymethyl)acrylate
中文名称
菜蓟苦素
分子式
C19H22O6
分子量
346.37900000000013 g/mol
SMILES
C=C1C[C@@H]([C@@H]2[C@H]([C@@H]3[C@H]1C[C@@H](C3=C)O)OC(=O)C2=C)OC(=O)C(=C)CO
InChIKey
KHSCYOFDKADJDJ-JNNCMOEMSA-N
最后更新: 2025-10-08 00:58
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