化合物问答
安西奈德(CAS号：51022-69-6)通常如何合成？
答案
![2-[(4a'S,4b'R,5'S,6a'S,6b'S,9a'R,10a'S,10b'S)-4b'-Fluoro-5'-hydroxy-4a',6a'-dimethyl-2'-oxo-2',4a',4b',5',6',6a',9a',10',10a',10b',11',12'-dodecahydro-6b'H-spiro[cyclopentane-1,8'-naphtho[2',1':4,5]in
deno[1,2-d][1,3]dioxol]-6b'-yl]-2-oxoethyl acetate](https://cnstatic.chemtradehub.com/structs/510/51022-69-6-c351.webp "2-[(4a'S,4b'R,5'S,6a'S,6b'S,9a'R,10a'S,10b'S)-4b'-Fluoro-5'-hydroxy-4a',6a'-dimethyl-2'-oxo-2',4a',4b',5',6',6a',9a',10',10a',10b',11',12'-dodecahydro-6b'H-spiro[cyclopentane-1,8'-naphtho[2',1':4,5]in
deno[1,2-d][1,3]dioxol]-6b'-yl]-2-oxoethyl acetate")
安西奈德通常通过多步合成方法制备，常见的合成路线涉及从1-氧代-2-氧杂-4-氮杂-14-氢螺[2.4]壬-10-烯-4-酮出发，通过底物导向的官能团转化得到目标化合物。这一方法利用了各种催化剂和保护基策略，确保选择性和高产率。
关于
CAS号
51022-69-6
英文名称
2-[(4a'S,4b'R,5'S,6a'S,6b'S,9a'R,10a'S,10b'S)-4b'-Fluoro-5'-hydroxy-4a',6a'-dimethyl-2'-oxo-2',4a',4b',5',6',6a',9a',10',10a',10b',11',12'-dodecahydro-6b'H-spiro[cyclopentane-1,8'-naphtho[2',1':4,5]in
deno[1,2-d][1,3]dioxol]-6b'-yl]-2-oxoethyl acetate
中文名称
安西奈德
分子式
C28H35FO7
分子量
502.58 g/mol
SMILES
CC(=O)OCC(=O)[C@]12OC3(CCCC3)O[C@@H]2C[C@H]4[C@@H]5CCC6=CC(=O)C=C[C@]6(C)[C@@]5(F)[C@@H](O)C[C@@]41C
InChIKey
ILKJAFIWWBXGDU-MOGDOJJUSA-N
最后更新: 2025-10-17 13:01
![2-[(4a'S,4b'R,5'S,6a'S,6b'S,9a'R,10a'S,10b'S)-4b'-Fluoro-5'-hydroxy-4a',6a'-dimethyl-2'-oxo-2',4a',4b',5',6',6a',9a',10',10a',10b',11',12'-dodecahydro-6b'H-spiro[cyclopentane-1,8'-naphtho[2',1':4,5]in
deno[1,2-d][1,3]dioxol]-6b'-yl]-2-oxoethyl acetate — 上海绩祥生物科技有限公司](https://cnstatic.chemtradehub.com/suppliers/67ce6f4d2b2de6e8e95a45bf/67ce6f4d2b2de6e8e95a45bf-logo.webp){kind=logo}
![2-[(4a'S,4b'R,5'S,6a'S,6b'S,9a'R,10a'S,10b'S)-4b'-Fluoro-5'-hydroxy-4a',6a'-dimethyl-2'-oxo-2',4a',4b',5',6',6a',9a',10',10a',10b',11',12'-dodecahydro-6b'H-spiro[cyclopentane-1,8'-naphtho[2',1':4,5]in
deno[1,2-d][1,3]dioxol]-6b'-yl]-2-oxoethyl acetate — 湖北扬信医药科技有限公司](https://cnstatic.chemtradehub.com/suppliers/67cded3957537e5c8069af88/67cded3957537e5c8069af88-logo.webp){kind=logo}