化合物问答
GSK- 1265744标准品(CAS号：1051375-10-0)通常如何合成？
答案
![(3S,11aR)-N-(2,4-Difluorobenzyl)-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide](https://cnstatic.chemtradehub.com/structs/105/1051375-10-0-b048.webp "(3S,11aR)-N-(2,4-Difluorobenzyl)-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide")
GSK-1265744标准品通常通过多步骤合成得到，包括缩合、环化和保护基的引入与脱除等过程。合成中常使用DFTB催化剂，产率可达80%以上。合成路线较为复杂，包含多个化学反应步骤。
关于
CAS号
1051375-10-0
英文名称
(3S,11aR)-N-(2,4-Difluorobenzyl)-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide
中文名称
GSK- 1265744标准品
分子式
C19H17F2N3O5
分子量
405.35 g/mol
SMILES
C[C@H]1CO[C@@H]2Cn3cc(C(=O)NCc4ccc(F)cc4F)c(=O)c(O)c3C(=O)N12
InChIKey
WCWSTNLSLKSJPK-LKFCYVNXSA-N
最后更新: 2025-10-19 20:29
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