化合物问答
甲箕(1R,2S,3S,5S)-3-(4-氟笨基)-8-甲箕-8-氮杂双环[3.2.1]辛烷-2-甲蒜酯(CAS号：50370-56-4)通常如何合成？
答案
![methyl (1R,2S,3S,5S)-3-(4-fluorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate](https://cnstatic.chemtradehub.com/structs/503/50370-56-4-c6a4.webp "methyl (1R,2S,3S,5S)-3-(4-fluorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate")
该化合物通常通过将3-氨基-8-甲基氮杂双环[3.2.1]辛烷-2-甲酸酯与4-氟苯甲酰氯反应合成。反应需要在无水条件下进行，通常使用DMF作为溶剂，反应温度控制在20-30℃，产率可达80%以上。
关于
CAS号
50370-56-4
英文名称
methyl (1R,2S,3S,5S)-3-(4-fluorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate
中文名称
甲箕(1R,2S,3S,5S)-3-(4-氟笨基)-8-甲箕-8-氮杂双环[3.2.1]辛烷-2-甲蒜酯
分子式
C16H20FNO2
分子量
277.33 g/mol
SMILES
CN1C2CCC1C(C(C2)C3=CC=C(C=C3)F)C(=O)OC
InChIKey
QUSLQENMLDRCTO-YJNKXOJESA-N
最后更新: 2025-11-01 18:55
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