化合物问答
AM-2394(CAS号：1442684-77-6)通常如何合成？
答案
![1-{6'-(2-Hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy]-3,3'-bipyridin-6-yl}-3-methylurea](https://cnstatic.chemtradehub.com/structs/144/1442684-77-6-8cc1.webp "1-{6'-(2-Hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy]-3,3'-bipyridin-6-yl}-3-methylurea")
AM-2394通常通过多步反应合成，首先合成3,3'-bipyridine-6-yl-2-hydroxy-2-methylpropoxide中间体，然后通过芳环上的亲电取代反应引入吡啶环，最后与甲基尿素反应得到目标化合物。常用的催化剂包括三乙胺、N-甲基吗啉等，总产率可达70%以上。
关于
CAS号
1442684-77-6
英文名称
1-{6'-(2-Hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy]-3,3'-bipyridin-6-yl}-3-methylurea
中文名称
AM-2394
分子式
C22H25N5O4
分子量
423.4730000000002 g/mol
SMILES
Cc1cc(cnc1)Oc2cc(ncc2c3ccc(nc3)OCC(C)(C)O)NC(=O)NC
InChIKey
QUISANLDBDCMPD-UHFFFAOYSA-N
最后更新: 2025-11-04 13:04
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