化合物问答
1H-螺[异喹啉-4(1H),4'-哌啶]-2(3H)-甲酸叔丁酯(CAS号：857898-70-5)通常如何合成？
答案
![2-Methyl-2-propanyl 1H-spiro[isoquinoline-4,4'-piperidine]-2(3H)-carboxylate](https://cnstatic.chemtradehub.com/structs/857/857898-70-5-78ff.webp "2-Methyl-2-propanyl 1H-spiro[isoquinoline-4,4'-piperidine]-2(3H)-carboxylate")
该化合物通常通过异喹啉和1-叔丁氧基羰基哌啶的缩合反应合成。首先，异喹啉与1-叔丁氧基羰基哌啶在合适的溶剂（如二氯甲烷或四氢呋喃）中反应，然后通过加热或使用催化剂促进环合反应。产率为80%左右。
关于
CAS号
857898-70-5
英文名称
2-Methyl-2-propanyl 1H-spiro[isoquinoline-4,4'-piperidine]-2(3H)-carboxylate
中文名称
1H-螺[异喹啉-4(1H),4'-哌啶]-2(3H)-甲酸叔丁酯
分子式
C18H26N2O2
分子量
302.42 g/mol
SMILES
CC(C)(C)OC(=O)N1CC2=CC=CC=C2C3(C1)CCNCC3
InChIKey
PYRPHEQXDLNURT-UHFFFAOYSA-N
最后更新: 2025-12-25 18:29
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