化合物问答
Elacestrant(CAS号：722533-56-4)通常如何合成？
答案
![(6R)-6-[2-(Ethyl{4-[2-(ethylamino)ethyl]benzyl}amino)-4-methoxyphenyl]-5,6,7,8-tetrahydro-2-naphthalenol](https://cnstatic.chemtradehub.com/structs/722/722533-56-4-0247.webp "(6R)-6-[2-(Ethyl{4-[2-(ethylamino)ethyl]benzyl}amino)-4-methoxyphenyl]-5,6,7,8-tetrahydro-2-naphthalenol")
Elacestrant通常通过多步骤合成得到，首先合成中间体，然后通过亲核取代反应将中间体连接到目标骨架上。该合成路线涉及了还原、保护基修饰、偶联等多个步骤。常用的催化剂和试剂包括钯催化剂、三氟乙酸等，总产率大约为50%左右。
关于
CAS号
722533-56-4
英文名称
(6R)-6-[2-(Ethyl{4-[2-(ethylamino)ethyl]benzyl}amino)-4-methoxyphenyl]-5,6,7,8-tetrahydro-2-naphthalenol
中文名称
Elacestrant
分子式
C30H38N2O2
分子量
458.65 g/mol
SMILES
CCNCCc1ccc(cc1)CN(CC)c2cc(ccc2[C@@H]3CCc4cc(ccc4C3)O)OC
InChIKey
SIFNOOUKXBRGGB-AREMUKBSSA-N
最后更新: 2025-12-28 14:56
![(6R)-6-[2-(Ethyl{4-[2-(ethylamino)ethyl]benzyl}amino)-4-methoxyphenyl]-5,6,7,8-tetrahydro-2-naphthalenol — MedChemExpress LLC](https://cnstatic.chemtradehub.com/suppliers/67ced0fb2b2de6e8e95a67fd/67ced0fb2b2de6e8e95a67fd-logo.webp){kind=logo}
![(6R)-6-[2-(Ethyl{4-[2-(ethylamino)ethyl]benzyl}amino)-4-methoxyphenyl]-5,6,7,8-tetrahydro-2-naphthalenol — 上海源叶生物科技有限公司](https://cnstatic.chemtradehub.com/suppliers/67ce9f132b2de6e8e95a48fe/67ce9f132b2de6e8e95a48fe-logo.webp){kind=logo}