化合物问答
3-环丙基-1-(2-氟-4-碘苯基)-6,8-二甲基-2,4,7-三氧代-1,2,3,4,7,8-六氢吡啶并[2,3-d]嘧啶-5-基 4-甲基苯磺酸盐(CAS号：871700-32-2)通常如何合成？
答案
![3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl 4-methylbenzenesulfonate](https://cnstatic.chemtradehub.com/structs/871/871700-32-2-f9fc.webp "3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl 4-methylbenzenesulfonate")
该化合物可以通过氟化碘苯与4-甲基苯磺酸钠在酸性条件下经多步反应合成。其中，关键步骤是通过缩合反应将环丙基引入目标分子中，随后通过氧化反应引入二甲基，最终通过磺酰化反应引入4-甲基苯磺酸基团。此过程通常需要使用催化剂，并且产率较高。
关于
CAS号
871700-32-2
英文名称
3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl 4-methylbenzenesulfonate
中文名称
3-环丙基-1-(2-氟-4-碘苯基)-6,8-二甲基-2,4,7-三氧代-1,2,3,4,7,8-六氢吡啶并[2,3-d]嘧啶-5-基 4-甲基苯磺酸盐
分子式
C25H21FIN3O6S
分子量
637.43 g/mol
SMILES
O=S(C1=CC=C(C)C=C1)(OC(C(C(N2C3CC3)=O)=C4N(C5=CC=C(I)C=C5F)C2=O)=C(C)C(N4C)=O)=O
InChIKey
RCCOZJPSLZNDFV-UHFFFAOYSA-N
最后更新: 2025-12-31 06:49
![3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl 4-methylbenzenesulfonate — 广东莱佛士制药技术有限公司](https://cnstatic.chemtradehub.com/suppliers/67ced1a42b2de6e8e95a6984/67ced1a42b2de6e8e95a6984-logo.webp){kind=logo}
![3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl 4-methylbenzenesulfonate — 上海源叶生物科技有限公司](https://cnstatic.chemtradehub.com/suppliers/67ce9f132b2de6e8e95a48fe/67ce9f132b2de6e8e95a48fe-logo.webp){kind=logo}
![3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl 4-methylbenzenesulfonate — 上海吉至生化科技有限公司](https://cnstatic.chemtradehub.com/suppliers/67cecbee2b2de6e8e95a5b72/67cecbee2b2de6e8e95a5b72-logo.webp){kind=logo}
![3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl 4-methylbenzenesulfonate — 乐研试剂](https://cnstatic.chemtradehub.com/suppliers/67ce1f8657537e5c8069b370/67ce1f8657537e5c8069b370-logo.webp){kind=logo}