化合物问答
(1R,5S,8S)-8-(BOC-氨基)-3-氮杂双环[3.2.1]辛烷(CAS号：847862-26-4)通常如何合成？
答案
![2-Methyl-2-propanyl (8-anti)-3-azabicyclo[3.2.1]oct-8-ylcarbamate](https://cnstatic.chemtradehub.com/structs/847/847862-26-4-d472.webp "2-Methyl-2-propanyl (8-anti)-3-azabicyclo[3.2.1]oct-8-ylcarbamate")
(1R,5S,8S)-8-(BOC-氨基)-3-氮杂双环[3.2.1]辛烷通常通过缩合反应合成，首先将3-氮杂双环[3.2.1]辛-8-酮与Boc-保护的胺反应，生成目标化合物。常用的催化剂是DCC（N,N'-二环己基碳二亚胺）和HOBt（1-羟基苯并三唑），产率可达70%-80%。
关于
CAS号
847862-26-4
英文名称
2-Methyl-2-propanyl (8-anti)-3-azabicyclo[3.2.1]oct-8-ylcarbamate
中文名称
(1R,5S,8S)-8-(BOC-氨基)-3-氮杂双环[3.2.1]辛烷
分子式
C12H22N2O2
分子量
226.31999999999996 g/mol
SMILES
CC(C)(C)OC(=O)N[C@@H]1[C@@H]2CC[C@H]1CNC2
InChIKey
HHYUNZXSGVNMOY-ILWJIGKKSA-N
最后更新: 2026-01-13 06:10
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