化合物问答
(1R,4R,5R)-rel-tert-Butyl 5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate(CAS号：198835-07-3)通常如何合成？
答案
![2-Azabicyclo[2.2.1]heptane-2-carboxylic acid, 5-hydroxy-, 1,1-dimethylethyl ester, (1R,4R,5R)-rel-](https://cnstatic.chemtradehub.com/structs/198/198835-07-3-a6ce.webp "2-Azabicyclo[2.2.1]heptane-2-carboxylic acid, 5-hydroxy-, 1,1-dimethylethyl ester, (1R,4R,5R)-rel-")
(1R,4R,5R)-rel-tert-Butyl 5-羟基-2-氮杂二环[2.2.1]庚烷-2-羧酸通常通过不对称合成方法制备，使用手性催化剂如手性辅基或手性双膦配体与环己酮衍生物反应，再经过保护基引入、脱保护等一系列步骤完成合成。产率通常可以达到50%-70%。
关于
CAS号
198835-07-3
英文名称
2-Azabicyclo[2.2.1]heptane-2-carboxylic acid, 5-hydroxy-, 1,1-dimethylethyl ester, (1R,4R,5R)-rel-
中文名称
(1R,4R,5R)-rel-tert-Butyl 5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate
分子式
C11H19NO3
分子量
213.27 g/mol
SMILES
O[C@@H]1C[C@H]2C[C@@H]1CN2C(=O)OC(C)(C)C
InChIKey
HDPGSWMTDGGUEB-IWSPIJDZSA-N
最后更新: 2026-03-05 06:57
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