化合物问答
7-(1,1-Dimethylethyl) 2-methyl 3-bromo-7-azabicyclo[2.2.1]hepta-2,5-diene-2,7-dicarboxylate(CAS号：181873-33-6)通常如何合成？
答案
![7-(1,1-Dimethylethyl) 2-methyl 3-bromo-7-azabicyclo[2.2.1]hepta-2,5-diene-2,7-dicarboxylate](https://cnstatic.chemtradehub.com/structs/181/181873-33-6-ad05.webp "7-(1,1-Dimethylethyl) 2-methyl 3-bromo-7-azabicyclo[2.2.1]hepta-2,5-diene-2,7-dicarboxylate")
该化合物通常通过分子间缩合反应合成，使用1,3-二氧戊环作为环化剂，与7-氨基-2-甲基-2,5-庚二烯-7-醇在碱性条件下反应，得到目标化合物。该方法的选择性较高，产率可达80%以上。
关于
CAS号
181873-33-6
英文名称
7-(1,1-Dimethylethyl) 2-methyl 3-bromo-7-azabicyclo[2.2.1]hepta-2,5-diene-2,7-dicarboxylate
分子式
C13H16BrNO4
分子量
330.1744 g/mol
SMILES
COC(=O)C1=C(Br)C2N(C1C=C2)C(=O)OC(C)(C)C
InChIKey
IYDVHSSMGFFQGK-UHFFFAOYSA-N
最后更新: 2026-03-08 04:51
![查看上海源叶生物科技有限公司的7-(1,1-Dimethylethyl) 2-methyl 3-bromo-7-azabicyclo[2.2.1]hepta-2,5-diene-2,7-dicarboxylate](https://cnstatic.chemtradehub.com/suppliers/67ce9f132b2de6e8e95a48fe/67ce9f132b2de6e8e95a48fe-logo.webp){kind=logo}
![查看江苏艾康生物医药研发有限公司的7-(1,1-Dimethylethyl) 2-methyl 3-bromo-7-azabicyclo[2.2.1]hepta-2,5-diene-2,7-dicarboxylate](https://cnstatic.chemtradehub.com/suppliers/67cec9452b2de6e8e95a52fa/67cec9452b2de6e8e95a52fa-logo.webp){kind=logo}
![查看金锦乐（湖南）化学有限公司的7-(1,1-Dimethylethyl) 2-methyl 3-bromo-7-azabicyclo[2.2.1]hepta-2,5-diene-2,7-dicarboxylate](https://cnstatic.chemtradehub.com/suppliers/67ce76192b2de6e8e95a464e/67ce76192b2de6e8e95a464e-logo.webp){kind=logo}
![查看乐研试剂的7-(1,1-Dimethylethyl) 2-methyl 3-bromo-7-azabicyclo[2.2.1]hepta-2,5-diene-2,7-dicarboxylate](https://cnstatic.chemtradehub.com/suppliers/67ce1f8657537e5c8069b370/67ce1f8657537e5c8069b370-logo.webp){kind=logo}