化合物问答
5-溴-4-甲基-2-[4-(三氟甲基)苯基]-1,3-噻唑(CAS号：850375-27-8)通常如何合成？
答案
![5-Bromo-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole](https://cnstatic.chemtradehub.com/structs/850/850375-27-8-715f.webp "5-Bromo-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole")
5-溴-4-甲基-2-[4-(三氟甲基)苯基]-1,3-噻唑通常通过芳环溴化和噻唑环的构建进行合成。首先，将4-甲基-2-苯基-1,3-噻唑与4-(三氟甲基)苯酚进行溴化反应，可以得到目标化合物。此合成方法通常在碱性条件下进行，使用催化剂如四丁基溴化铵等。产率约为70%-80%。
关于
CAS号
850375-27-8
英文名称
5-Bromo-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole
中文名称
5-溴-4-甲基-2-[4-(三氟甲基)苯基]-1,3-噻唑
分子式
C11H7BrF3NS
分子量
322.15 g/mol
SMILES
Cc1c(sc(n1)c2ccc(cc2)C(F)(F)F)Br
InChIKey
BZCIYGNYGIKEEC-UHFFFAOYSA-N
最后更新: 2026-03-16 17:23
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