化合物问答
索利那新相关化合物 3 Succinate(CAS号：862207-70-3)通常如何合成？
答案
![(3R)-1-azabicyclo[2.2.2]octan-3-yl (1R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate, butanedioic acid](https://cnstatic.chemtradehub.com/structs/862/862207-70-3-4d92.webp "(3R)-1-azabicyclo[2.2.2]octan-3-yl (1R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate, butanedioic acid")
该化合物通常通过缩合和酰化反应合成。首先，以(3R)-1-azabicyclo[2.2.2]octan-3-yl(1R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate为起始原料，通过酰化反应引入琥珀酸基团，得到目标化合物。该反应在温和条件下进行，产率约为85%。
关于
CAS号
862207-70-3
英文名称
(3R)-1-azabicyclo[2.2.2]octan-3-yl (1R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate, butanedioic acid
中文名称
索利那新相关化合物 3 Succinate
分子式
C27H32N2O6
分子量
480.56 g/mol
SMILES
OC(=O)CCC(=O)O.O=C(O[C@H]1CN2CC[C@H]1CC2)N3CCc4ccccc4[C@H]3c5ccccc5
InChIKey
RXZMMZZRUPYENV-UMIAIAFLSA-N
最后更新: 2026-03-26 04:30
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