化合物问答
依杜沙班盐酸盐标准品(CAS号：480448-29-1)通常如何合成？
答案
![N-(5-Chloro-2-pyridinyl)-N'-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-{[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbonyl]amino}cyclohexyl]ethanediamide hydrochloride (1:1)](https://cnstatic.chemtradehub.com/structs/480/480448-29-1-d027.webp "N-(5-Chloro-2-pyridinyl)-N'-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-{[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbonyl]amino}cyclohexyl]ethanediamide hydrochloride (1:1)")
依杜沙班盐酸盐标准品通常通过多步合成过程制备。首先，通过偶联反应将含有氯吡啶基团的化合物与含有氨基的化合物反应，生成中间体。接着，通过酰胺化反应将中间体与含有羧基的化合物作用，生成目标化合物。该过程通常在温和的条件下进行，需要使用催化剂提高反应的选择性和产率。
关于
CAS号
480448-29-1
英文名称
N-(5-Chloro-2-pyridinyl)-N'-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-{[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbonyl]amino}cyclohexyl]ethanediamide hydrochloride (1:1)
中文名称
依杜沙班盐酸盐标准品
分子式
C24H31Cl2N7O4S
分子量
584.53 g/mol
SMILES
CN1CCc2c(sc(n2)C(=O)N[C@@H]3C[C@H](CC[C@@H]3NC(=O)C(=O)Nc4ccc(cn4)Cl)C(=O)N(C)C)C1.Cl
InChIKey
ZQYCNCZOSSOOQR-QXXZOGQOSA-N
最后更新: 2026-03-29 12:16
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