4-Nitrobenzyl (5R,6S)-6-[(1R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylate（CAS号：74288-40-7）

亚胺培南母核

基本信息

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CAS号

74288-40-7

分子式

C16H16N2O7

分子量

348.31 g/mol

化学分类

基础化工原料有机化学品羧酸类

基础化工原料有机化学品酮类

基础化工原料有机化学品酯类

基础化工原料有机化学品醚类

基础化工原料有机化学品杂环化合物

医药化工医药中间体杂环中间体

精细化工产品染料和颜料有机染料

精细化工产品表面活性剂阴离子表面活性剂

基本物理性质

熔点

109-114°C

沸点

607.5°C at 760 mmHg

比旋光度

188-210° (c=1 in DMF)

SMILES

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CC(C1C2CC(=O)C(N2C1=O)C(=O)OCC3=CC=C(C=C3)[N+](=O)[O-])O

InChI

InChI=1S/C16H16N2O7/c1-8(19)13-11-6-12(20)14(17(11)15(13)21)16(22)25-7-9-2-4-10(5-3-9)18(23)24/h2-5,8,11,13-14,19H,6-7H2,1H3/t8-,11-,13-,14?/m1/s1

InChIKey

YBIDYTOJOXKBLO-USLOAXSXSA-N

LogP

0.64830

复杂度

594

安全信息

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危险说明

H302 吞咽有害
急性毒性-经口

H315 造成皮肤刺激
皮肤腐蚀/刺激

H319 造成严重眼刺激
严重眼损伤/眼刺激

H332 吸入有害
急性毒性-吸入

H335 可能造成呼吸道刺激
特定目标器官毒性-单次接触；呼吸道刺激

同义词与引用数据

英文

YBIDYTOJOXKBLO-USLOAXSXSA-N
NS00037607
UNII-V9J4CAR06A
BCP12985
4-Nitrobenzyl (5R,6S)-6-[(1R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylate, Antibiotic for Culture Media Use O nly
4-nitrobenzyl (5R,6S)-6-((1R)-1-hydroxyethyl) -2-oxo-1-carbapenam-3-carboxylate
DTXSID10225303
ADC13
(4-nitrophenyl)methyl (5R,6S)-6-[(1R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylate
AKOS015950836
AKOS040744495
(5R,6S)-4-Nitrobenzyl6-((R)-1-hydroxyethyl)-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylate
(5R,6S) p-nitrobenzyl 6-[(R)-1-hydroxyethyl]-1-azabicyclo[3.2.0]heptan-3,7-dione-2-carboxylate
6-[(1R)-1-Hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid (5R,6S)-(4-nitrophenyl)methyl ester
4-nitrobenzyl (5R, 6S)-6-[(1R)-1-hydroxyethyl]-2oxo-1-carbapenam-3-carboxylate
p-nitrobenzyl (5R, 6S)-6-[1-(R)-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylate
Q27291699
4-nitrobenzyl (5R,6S)-2-oxo-6-((1R)-1-hydroxyethyl) -1-carbapenam-3-carboxylate
p-Nitrobenzyl 6-(1'-Hydroxyethyl)-azabicyclo(3.2.0)heptane-3,7-dione-2-carboxylate
p-Nitrobenzyl (5R,6S)-6-((1R)-1-hydroxyethyl)-2-oxocarbapenam-3-carboxylate
ADC-13
4-nitrobenzyl (5R,6S)-6-[(1R)-1-hydroxyethyl]-2-oxo-1-carbapenam-3-carboxylate
1-Azabicyclo[3.2.0]heptane-2-carboxylicacid, 6-[(1R)-1-hydroxyethyl]-3,7-dioxo-, (4-nitrophenyl)methyl ester, (5R,6S)-
p-nitrobenzyl (5R, 6S)-6-[(1R)-1-hydroxyethyl]-2-oxo-1-carbapenam-3-carboxylate
4-nitrobenzyl (5R,6S)-3,7-dioxo-6-{(1R)-1-hydroxyethyl}-1-azabicyclo[3.2.0]heptane-2-carboxylate
4-nitrobenzyl (5R, 6S)-6-[(1R)-1-hydroxyethyl]-2-oxo-1-carbapenam-3-carboxylate
(5R,6S)-4-Nitrobenzyl 6-((R)-1-hydroxyethyl)-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylate
p-Nitrobenzyl-6-(1-hydroxyethyl)-1-azabicyclo(3.2.0)heptane-3,7-dione-2-carboxylate
DS-2916
Q-101437
V9J4CAR06A

中文

4-硝基苄基-(5R,6S)-6-[1R]-1-羟基乙基]-3,7-二酮-1-氮杂双环[3.2.0]庚烷-2-羧酸酯
亚胺培南母核
碳青霉烯双环母核
4-硝基苄基-(5R,6S)-6-[1R]-1-羟基乙基]-3,7-二酮-1-氮杂双环
亚胺培南和帕尼培南双环母核
亚胺培南母核(BCK)
亚胺培南双环母核
亚胺母核
亚胺培南母核BCK

MDL号

MFCD08458409

海关编码

2933990090

常见问题

什么是亚胺培南母核(CAS号：74288-40-7)？

亚胺培南母核是一种有机化合物，化学结构为4-Nitrobenzyl (5R,6S)-6-[(1R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylate。它作为β-内酰胺酶抑制剂，常用于抗生素药物的设计中，特别是与碳青霉烯类抗生素结合，以增强其对耐药菌的抗菌效果。该化合物在药理学中具有重要的应用价值，是多种广谱抗生素的核心结构之一。