ACS Medicinal Chemistry Letters

ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, drug interactome studies, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to: Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics) Biological characterization of new molecular entities in the context of drug discovery towards delineating structure-activity relationship (SAR) trends Computational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands, and their targets, etc. Use of artificial intelligence and machine learning in drug discovery Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistry if the methods have been tested on relevant molecules. (e.g. DNA-encoded libraries, high-throughput experimentation, high-throughput parallel synthesis- compound library production, fragment-based drug discovery, covalent modulators.) New developments in discovery screening and bioassay technologies for biologically active molecules from both synthetic and natural (plant and other) sources. Chemistry patents relevant to the medicinal chemistry field Studies involving proximity-inducing agents including targeted protein degradation and molecular glues.