Overoxidation of carbon-fiber microelectrodes enhances dopamine adsorption and increases sensitivity

文献信息

发布日期 2003-11-11

DOI 10.1039/B307024G

影响因子 4.616

作者

Michael L. A. V. Heien, Paul E. M. Phillips, Garret D. Stuber, Andrew T. Seipel, R. Mark Wightman

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摘要

The voltammetric responses of carbon-fiber microelectrodes with a 1.0 V and a 1.4 V anodic limit were compared in this study. Fast-scan cyclic voltammetry was used to characterize the response to dopamine and several other neurochemicals. An increase in the adsorption properties of the carbon fiber leads to an increase in sensitivity of 9 fold in vivo. However the temporal response of the sensor is slower with the more positive anodic limit. Increased electron transfer kinetics also causes a decrease in the relative sensitivity for dopamine vs. other neurochemicals, and a change in their cyclic voltammograms. Stimulated release in the caudate-putamen was pharmacologically characterized in vivo using Ro-04-1284 and pargyline, and was consistent with that expected for dopamine.

期刊推荐

Chinese Journal of Chemistry

Critical Reviews in Solid State and Materials Sciences

Topics in Catalysis

Cellulose

Acta Metallurgica Sinica-English Letters

Atomization and Sprays

Main Group Chemistry

Colloid Journal

Herald of the Russian Academy of Sciences

Bioorganic & Medicinal Chemistry

来源期刊

Analyst

CiteScore: 7.8

自引率: 5.6%

年发文量: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

Overoxidation of carbon-fiber microelectrodes enhances dopamine adsorption and increases sensitivity

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