The structure of nanotubes formed by diphenylalanine, the core recognition motif of Alzheimer's β-amyloid polypeptide
文献信息
Carl Henrik Görbitz
Alzheimer's β-amyloid diphenylalanine motif has previously been shown to self-assemble into discrete and extraordinary stiff nanotubes; these nanotubes were initially thought to be distinct from the single crystal structure of diphenylalanine, but it is now shown that the X-ray powder diffraction pattern of the nanotubes is identical to the simulated pattern for the single crystal structure, affording a new foundation for understanding and rationalizing the properties of this remarkable organic material.
期刊推荐

Nature Reviews Drug Discovery

European Journal of Organic Chemistry

CrystEngComm

Green Chemistry

Journal of Medical Biochemistry

Mini-Reviews in Medicinal Chemistry

Environmental Toxicology and Pharmacology

Advanced Engineering Materials

Photochemical & Photobiological Sciences

Current Pharmaceutical Biotechnology
相关文献
Simulation of maintenance of the epidermis
Bengt Kasemo
DOI: 10.1039/B205795F
Molar volume of 6Li, 7Li and natural Li in the liquid state
Yuta Shimizu, Akitoshi Mizuno, Tadahiko Masaki
DOI: 10.1039/B201956F
Density functional theoretical (DFT) and surface-enhanced Raman spectroscopic study of guanine and its alkylated derivatives Part 1. DFT calculations on neutral, protonated and deprotonated guanine
Bernd Giese, Don McNaughton
DOI: 10.1039/B203829C
Optically induced birefringence in a series of analogous diols
DOI: 10.1039/B203010A
A physical mechanism for large-ion selectivity of ion channels
Douglas Henderson, Robert S. Eisenberg
DOI: 10.1039/B203184A
Phase transition in swollen gels Part 32. Temperature transition in charged poly(N-isopropylmethacrylamide) hydrogels in water and aqueous NaCl solutions
A. Fomenko, H. Pospíšil, Z. Sedláková, J. Pleštil
DOI: 10.1039/B203378J
Synthesis of a BaO thin film supported on MgO(001) using a shell-model amorphisation and recrystallisation strategy
Dean C. Sayle, S. Andrada Maicaneanu, Graeme W. Watson
DOI: 10.1039/B205725P
Intramolecular charge-transfer properties of a molecule with a large donor group: the case of 4′-(pyren-1-yl)benzonitrile
J. Dobkowski, W. Rettig, J. Waluk
DOI: 10.1039/B204749G
DFT study of inner-sphere electron transfer in a gas-phase SN2 reaction at the saturated carbon
Yu-Mei Xing, Xiu-Fang Xu, Lan Chen, Zun-Sheng Cai, Xue-Zhuang Zhao, Jin-Pei Cheng
DOI: 10.1039/B202613A
Correlated ab initio study of nucleic acid bases and their tautomers in the gas phase, in a microhydrated environment and in aqueous solution Part 1. Cytosine
Semen A. Trygubenko, Tetyana V. Bogdan, Manuel Rueda, Modesto Orozco, F. Javier Luque, Jiří Šponer, Petr Slavíček, Pavel Hobza
DOI: 10.1039/B202156K
您可能还喜欢
如何处理含有顺-二(2,2'-联吡啶)二氯化钌(II)二水合物(CAS号:67776-38-9)的废料?
处理含有该化合物的废料时,应先收集并分类,然后根据其危险特性选择合适的处理方法。推荐采用焚烧或由专业机构进行安全处理,以确保符合环保法规的要求。处理过程中应佩戴...
4-amino-2-bromo-3-iodopyridine(CAS号:1300750-77-9)的市场或研究趋势如何?
4-氨基-2-溴-3-碘吡啶主要应用于药物合成和研究领域,尤其是在抗病毒和抗癌药物的研发中。随着新型药物的需求增加,该化合物的研究趋势较好。市场方面,由于其特殊...
4-乙酰基氨基-2-氨基-苯甲酸(CAS号:43134-76-5)的市场或研究趋势如何?
当前,4-乙酰基氨基-2-氨基-苯甲酸(CAS号:43134-76-5)在医药和化工领域有一定的应用。随着药物研发的进展,该化合物在新型药物设计中的应用可能增加...
庚a氟-1-(1-碘-1,2,2,2-四氟乙氧基)丙烷(CAS号:107432-46-2)的市场或研究趋势如何?
该化合物目前主要用于特定的工业应用,如氟聚合物的合成。市场趋势显示,由于其独特的结构和性能,未来可能在新型氟材料和特种化学品领域有更多的应用。研究趋势方面,主要...
在合成中是否有Propargyl-PEG13-bromide(CAS号:2055105-25-2)的替代品?
可以考虑使用1,3-丁二烯-1-炔-3-基-聚乙二醇-13-溴化物作为Propargyl-PEG13-bromide的替代品,因为两者在结构上相似,均可用于合成...
2-氨基-6-甲氧基嘌呤(CAS号:20535-83-5)安全吗?
2-氨基-6-甲氧基嘌呤在正常使用条件下相对安全,但在操作时仍需注意防护措施,如佩戴手套和护目镜,避免吸入或接触皮肤和眼睛。
2-甲基-3-溴苯乙酸乙酯(CAS号:1261862-72-9)适用哪些法规指南?
该化合物根据其化学性质和潜在危害,可能适用于GHS(全球化学品统一分类和标签制度)的分类标准。具体分类需依据其毒性和燃烧危险性进行评估。此外,欧洲化学品管理局(...
4,4-二甲基吡咯烷-3-羧酸盐酸盐(CAS号:1351343-41-3)应用于哪些行业?
4,4-二甲基吡咯烷-3-羧酸盐酸盐在医药、聚合物和传感器领域有应用。在医药领域,它可以作为某些药物的中间体;在聚合物领域,它可用作某些聚合物的稳定剂;在传感器...
处理5-Hydroxy-7-methoxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-6-yl 2-O-beta-D-xylopyranosyl-beta-D-glucopyranoside(CAS号:149998-39-0)时应注意哪些实验室安全事项?
处理该化合物时应注意使用个人防护装备(如手套、护目镜和实验服),在通风橱中操作。避免直接接触皮肤和吸入,泄漏时应立即清理并使用适当的吸收材料。参考安全数据表(S...
7-甲基-1,2,3,4-四氢-吖啶-9-甲酸(CAS号:345621-27-4)的市场或研究趋势如何?
该化合物在医药研究中具有潜在应用价值,特别是在抗癌药物研发方面。随着研究的深入,对其合成方法的优化和生物活性的进一步探索将成为研究热点。
来源期刊
Chemical Communications

ChemComm publishes urgent research which is of outstanding significance and interest to experts in the field, while also appealing to the journal’s broad chemistry readership. Our communication format is ideally suited to short, urgent studies that are of such importance that they require accelerated publication. Our scope covers all topics in chemistry, and research at the interface of chemistry and other disciplines (such as materials science, nanoscience, physics, engineering and biology) where there is a significant novelty in the chemistry aspects. Major topic areas covered include: Analytical Chemistry Catalysis Chemical Biology and medicinal chemistry Computational Chemistry and Machine Learning Energy and sustainable chemistry Environmental Chemistry Green Chemistry Inorganic Chemistry Materials Chemistry Nanoscience Organic Chemistry Physical Chemistry Polymer Chemistry Supramolecular Chemistry




![4-Nitrophenyl N-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-isoleucinate structure 4-Nitrophenyl N-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-isoleucinate structure](https://cnstatic.chemtradehub.com/structs/169/16948-38-2-c88f.webp)