Optical detection of singlet oxygen from single cells
文献信息
John W. Snyder, Esben Skovsen, John D. C. Lambert, Lars Poulsen, Peter R. Ogilby
The lowest excited electronic state of molecular oxygen, singlet molecular oxygen, O2(a 1Δg), is a reactive species involved in many chemical and biological processes. To better understand the roles played by singlet oxygen in biological systems, particularly at the sub-cellular level, optical tools have been developed to create and directly detect this transient state in time- and spatially-resolved experiments from single cells. Data obtained indicate that, contrary to common perception, this reactive species can be quite long-lived in a cell and, as such, can diffuse over appreciable distances including across the cell membrane into the extracellular environment. On one hand, these results demonstrate that the behavior of singlet oxygen in an intact cell can be significantly different from that inferred from model bulk studies. More generally, these results provide a new perspective for mechanistic studies of intra- and inter-cellular signaling and events that ultimately lead to photo-induced cell death.
期刊推荐

Molecules

Contact Lens & Anterior Eye

Current Pharmaceutical Biotechnology

Advanced Engineering Materials

Journal of Enzyme inhibition and Medicinal Chemistry

Mini-Reviews in Medicinal Chemistry

Angewandte Chemie International Edition

Foundations of Chemistry

European Journal of Organic Chemistry

Lab on a Chip
相关文献
Controlled nanostructures for applications in catalysis
Ferdi Schüth
DOI: 10.1039/C1CP90005F
Translation-rotation energy levels of one H2 molecule inside the small, medium and large cages of the structure H clathrate hydrate
Álvaro Valdés, Geert-Jan Kroes
DOI: 10.1039/C0CP01804J
Unfolding and refolding details of lysozyme in the presence of β-casein micelles
Fu-Gen Wu, Jun-Jie Luo, Zhi-Wu Yu
DOI: 10.1039/C0CP01184C
Stepwise vs. concerted pathways in scandium ion-coupled electron transfer from superoxide ion to p-benzoquinone derivatives
Tomonori Kawashima, Kei Ohkubo
DOI: 10.1039/C0CP00916D
Elastic deformations in hexagonal phases studied by small-angle X-ray diffraction and simulations
Šárka Perutková, Matej Daniel, Michael Rappolt, Georg Pabst, Gregor Dolinar, Veronika Kralj-Iglič, Aleš Iglič
DOI: 10.1039/C0CP01187H
Encapsulation of chiral Fe(salan) in nanocages with different microenvironments for asymmetric sulfide oxidation
Bo Li, Shiyang Bai, Peng Wang, Hengquan Yang, Qihua Yang, Can Li
DOI: 10.1039/C0CP01828G
One-pot generation of mesoporous carbon supported nanocrystalline calcium oxides capable of efficient CO2 capture over a wide range of temperatures
Na Hao, Gongkui Xiao, Liying Liu, Paul Webley
DOI: 10.1039/C0CP01807D
Geometric and electronic effects on hydrogenation of cinnamaldehyde over unsupported Pt-based nanocrystals
William O. Oduro, Nick Cailuo, Kai Man K. Yu, Hongwei Yang, Shik Chi Tsang
DOI: 10.1039/C0CP01832E
Ammonia IRMS-TPD measurements on Brønsted acidity of proton-formed SAPO-34
Katsuki Suzuki, Takuma Nishio, Naonobu Katada, German Sastre, Miki Niwa
DOI: 10.1039/C0CP00961J
您可能还喜欢
什么是2-Bromo-1-(pyrimidin-2-yl)ethanone hydrobromide(CAS号:1588441-02-4)?
2-Bromo-1-(pyrimidin-2-yl)ethanone hydrobromide是一种有机化合物,分子式为C6H5Br2N2O2。它是一种溴代化合...
在合成中是否有1-正-丁基-3-甲基咪唑鎓三氟甲烷磺酸盐(CAS号:174899-66-2)的替代品?
在合成中,可以考虑使用1-正-丁基-3-甲基咪唑鎓溴酸盐或1-正-丁基-3-甲基咪唑鎓氯酸盐作为替代品。这些化合物在性能上与1-正-丁基-3-甲基咪唑鎓三氟甲烷...
2-methyl-5-thiophen-2-ylfuran-3-carboxylic acid(CAS号:651005-90-2)的市场或研究趋势如何?
目前,2-methyl-5-thiophen-2-ylfuran-3-carboxylic acid的研究主要集中在药物化学和新型材料领域。随着生物医药和有机合...
格列吡嗪杂质H(CAS号:13554-93-3)的主要用途是什么?
格列吡嗪杂质H主要作为药物中间体或副产物存在,并无特定的工业应用。在药物生产中,它可能需要被处理掉以保证最终药物的质量。
如何储存(9ci)-4-甲氧基-1H-苯并咪唑-2-乙腈(CAS号:317817-41-7)?
(9ci)-4-甲氧基-1H-苯并咪唑-2-乙腈应储存在阴凉、干燥、通风良好的地方,避免阳光直射。使用密封的玻璃或塑料容器储存,并确保容器的密封性良好,以防止挥...
4,5,9,10-四氢苯芘(CAS号:781-17-9)应用于哪些行业?
4,5,9,10-四氢苯芘在医药行业用于作为某些药物的中间体,在聚合物行业用作添加剂提升材料的热稳定性,在传感器领域作为传感器的敏感材料,在半导体行业中用作掺杂...
处理叶酸-D4(CAS号:171777-72-3)时应注意哪些实验室安全事项?
处理叶酸-D4时应佩戴个人防护装备(PPE),如手套和实验服。操作应在通风橱内进行,以避免吸入蒸汽或粉尘。如果不慎泄露,应立即用大量清水冲洗,并通知安全人员。参...
如何处理含有6-溴-2-(三氟乙酰基)-1,2,3,4-四氢异喹啉(CAS号:252331-63-8)的废料?
含有该化合物的废料应收集到专用的容器中,并进行密封以防止挥发和泄漏。在处理前,需进行危险性评估,以确定是否需要进行化学处理。最终处置需遵循当地的危险废物管理规定...
4,5-二氟-2-甲氧基苯甲醛(CAS号:145742-34-3)的主要用途是什么?
4,5-二氟-2-甲氧基苯甲醛主要用作有机合成中的中间体,特别是在制药和农药领域。它可以作为合成其他有机化合物的原料。
5-溴-6-三氟甲基吲哚(CAS号:1198475-24-9)安全吗?
5-溴-6-三氟甲基吲哚作为一种化学试剂,具有一定的毒性,需要在通风橱中操作,并采取适当的安全措施以避免吸入、皮肤接触和眼睛刺激。应避免与皮肤和眼睛直接接触,并...
来源期刊
Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.




