Carboranyl thymidine analogues for neutron capture therapy

文献信息

发布日期 2007-08-15

DOI 10.1039/B707257K

影响因子 6.222

作者

Rohit Tiwari, Youngjoo Byun, Sureshbabu Narayanasamy

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摘要

Neutron capture therapy (NCT) is a binary radio-chemotherapeutic modality for the treatment of cancer. A major focus of NCT-related research is the development of novel tumor-selective agents that serve as the chemical component in NCT. Thymidine analogues substituted with a boron-containing carborane cluster at the N3 position, designated 3CTAs (3-carboranyl thymidine analogues), constitute one class of these new improved NCT agents. Their chemical, structural and biological properties are discussed in this Feature Article.

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来源期刊

Chemical Communications

CiteScore: 8.6

自引率: 4.7%

年发文量: 2458

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