Design of liposome-based pH sensitive nanoSPINprobes: nano-sized particles with incorporated nitroxides

文献信息

发布日期 2009-03-11

DOI 10.1039/B818184E

影响因子 4.616

作者

Andrey A. Bobko, Igor A. Kirilyuk, Julya F. Polienko, Maxim A. Voinov, Elena G. Bagryanskaya, Valery V. Khramtsov

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摘要

Liposome-based nanoSized Particles with Incorporated Nitroxides, or nanoSPINs, were designed for EPR applications as pH probes in biological systems. Phospholipid membrane of the liposomes with incorporated gramicidin A showed selective permeability to a small analyte, H+, while protecting entrapped sensing nitroxide from biological reductants. An application of the pH-sensitive nanoSPIN in an ischemia model in rat heart homogenate allows for monitoring ischemia-induced acidosis while protecting encapsulated nitroxide against bioreduction.

期刊推荐

Foundations of Chemistry

Contact Lens & Anterior Eye

Angewandte Chemie International Edition

Molecular Diversity

Journal of Enzyme inhibition and Medicinal Chemistry

Current Pharmaceutical Biotechnology

Journal of Medical Biochemistry

Advanced Engineering Materials

European Journal of Organic Chemistry

Environmental Toxicology and Pharmacology

来源期刊

Analyst

CiteScore: 7.8

自引率: 5.6%

年发文量: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

Design of liposome-based pH sensitive nanoSPINprobes: nano-sized particles with incorporated nitroxides

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