Sensitive and selective detection ofcysteine using gold nanoparticles as colorimetric probes

文献信息

发布日期 2009-04-02

DOI 10.1039/B819842J

影响因子 4.616

作者

Li Li, Baoxin Li

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摘要

We report herein the development of a highly sensitive and selective colorimetric detection method for cysteine using gold nanoparticles probes. This assay relies upon the distance-dependent optical properties of gold nanoparticles, the self-assembly of cysteine on gold nanoparticles, and the interaction of a 2:1 cysteine/Cu2+ complex. In the presence of Cu2+, cysteine could rapidly induce the aggregation of gold nanoparticles, thereby resulting in red-to-blue (or purple) color change. The concentration of cysteine can be determined by monitoring with the naked eye or a UV-vis spectrometer. The present limit of detection for cysteine is 10 nM. This method exhibits excellent selectivity for cysteine over other α-amino acids, glutathione, thioglycolic acid and mercaptoethyl alcohol.

期刊推荐

Polycyclic Aromatic Compounds

NDT & E International

Medicinal Chemistry Research

Bioorganic & Medicinal Chemistry Letters

Cellulose

Journal of Asian Natural Products Research

Biocatalysis and Biotransformation

Electroanalysis

Topics in Catalysis

Main Group Chemistry

来源期刊

Analyst

CiteScore: 7.8

自引率: 5.6%

年发文量: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

Sensitive and selective detection ofcysteine using gold nanoparticles as colorimetric probes

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