Lipid coated mesoporous silicananoparticles as photosensitive drug carriers
文献信息
Yang Yang, Weixing Song, Anhe Wang, Pengli Zhu, Jinbo Fei
This paper presents a strategy for the biofunctionalization of novel photosensitizer carriers, mesoporous silica nanoparticles (MSNs). After being calcined and absorbed with photosensitizers (hypocrellin B, HB), MSNs can be coated with a lipid layer. Transmission electron microscopy (TEM) and confocal laser scanning microscopy (CLSM) results proved that HB molecules can be loaded into MSN porous and lipid can coated on the surface of the nanoparticles. When co-cultured with cancer cells (MCF-7), MSNs can transport HB molecules into cells and present low cytotoxicity. With the introduction of a lipid layer, the efficiency of MSN uptake by cells can be improved. These intracellular HB-loaded MSN materials also present cytotoxicity to MCF-7 cells after light irradiation which indicates the materials can be used as good photosensitizer carriers in photodynamic therapy.
相关文献
An acetate bound cobalt oxide catalyst for water oxidation: role of monovalent anions and cations in lowering overpotential
Subal Dey, Biswajit Mondal, Abhishek Dey
DOI: 10.1039/C4CP01205D
13C NMR relaxation and reorientation dynamics in imidazolium-based ionic liquids: revising interpretation
Petri Ingman, Erkki Lähderanta
DOI: 10.1039/C4CP00637B
Ternary Pt/SnOx/TiO2 photocatalysts for hydrogen production: consequence of Pt sites for synergy of dual co-catalysts
Quan Gu, Jinlin Long, Huaqiang Zhuang, Chaoqiang Zhang, Yangen Zhou, Xuxu Wang
DOI: 10.1039/C4CP01496K
Enhancing photo-induced ultrafast charge transfer across heterojunctions of CdS and laser-sintered TiO2 nanocrystals
Bryan T. Spann, S. Venkataprasad Bhat, Qiong Nian, Kelly M. Rickey, Gary J. Cheng, Xiulin Ruan, Xianfan Xu
DOI: 10.1039/C4CP01298D
Intermolecular network analysis of the liquid and vapor interfaces of pentane and water: microsolvation does not trend with interfacial properties
Yasaman Ghadar, Aurora E. Clark
DOI: 10.1039/C4CP00602J
Computer simulation studies on passive recruitment dynamics of lipids induced by the adsorption of charged nanoparticles
DOI: 10.1039/C4CP00553H
Thermoresponsive fluorescence of a graphene–polymer composite based on a local surface plasmon resonance effect
Yunyun Huang, Wensheng Lin, Kan Chen, Wenkai Zhang, Xudong Chen, Ming Qiu Zhang
DOI: 10.1039/C4CP00773E
What makes zeolitic imidazolate frameworks hydrophobic or hydrophilic? The impact of geometry and functionalization on water adsorption
Aurélie U. Ortiz, Alexy P. Freitas, Anne Boutin, Alain H. Fuchs, François-Xavier Coudert
DOI: 10.1039/C3CP54292K
Clusters in the adsorbates of vapours and gases: Zeta isotherm approach
Seyed Hadi Zandavi, Charles A. Ward
DOI: 10.1039/C4CP00843J
Combined excitatory and inhibitory coupling in a 1-D array of Belousov–Zhabotinsky droplets
Ning Li, Irving R. Epstein, Seth Fraden
DOI: 10.1039/C4CP00957F
您可能还喜欢
十二烷基磺酸钠(CAS号:2386-53-0)的主要用途是什么?
十二烷基磺酸钠主要用作表面活性剂,广泛应用于洗涤剂、肥皂、化妆品和工业清洁产品中。它能有效去除油脂和污垢,常用于制造洗发水、沐浴露、洗衣粉和金属清洗剂。此外,它...
5-羟基异喹啉(CAS号:2439-04-5)适用哪些法规指南?
5-羟基异喹啉作为化学品,主要适用的法规包括GHS全球化学品统一分类和标签制度,REACH法规等。GHS将5-羟基异喹啉分类为皮肤腐蚀/刺激类别2,严重眼损伤/...
在合成中是否有FIDAS-5 | Wnt(CAS号:1391934-98-7)的替代品?
合成中可以考虑使用类似结构的化合物,如4-[(E)-2-(2-氯-6-氟苯基)乙烯基]-N-甲基苯胺的类似物或衍生物作为替代品。这类化合物可能具有相似的生物活性...
(R)-tert-Butyl 2-(5-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylate(CAS号:1370600-56-8)通常如何合成?
该化合物通常通过如下步骤合成:首先,将4-溴-1H-咪唑与对甲苯磺酸在乙酸乙酯中反应,得到中间体5-溴-1H-咪唑-2-甲酸乙酯。然后,该中间体与2-甲基-2-...
处理4-(吡咯烷-1-基)环己酮(CAS号:10421-18-8)时应注意哪些实验室安全事项?
处理4-(吡咯烷-1-基)环己酮时,应佩戴手套、护目镜和实验室外套,以防止直接接触或吸入。在通风橱中操作,确保良好的通风条件。一旦发生泄漏,应立即清理并使用适当...
如何处理含有异麦芽糖醇(CAS号:534-73-6)的废料?
含有异麦芽糖醇的废液应首先进行分类收集,避免与其他化学品混合。对于小规模的废液,可以通过焚烧或加入特定的化学试剂进行无害化处理。对于大规模的废液,建议联系专业的...
7-甲基壬酸(CAS号:41653-89-8)的主要用途是什么?
7-甲基壬酸主要用于有机合成领域,作为合成其他化合物的原料。此外,它还可能作为一种中间体用于药品制造和香料合成,但具体用途需要根据其具体的化学结构和反应特性来确...
N-甲氧基-N-甲基甲基吡啶羧酰胺(CAS号:148493-07-6)应用于哪些行业?
N-甲氧基-N-甲基甲基吡啶羧酰胺在医药领域有一定的应用,作为一种潜在的药物前体或中间体。此外,该化合物也可能应用于聚合物改性剂、传感器材料等。由于其独特的化学...
什么是惕各酸香叶酯(CAS号:7785-33-3)?
惕各酸香叶酯是一种化合物,化学名称为(2E)-3,7-二甲基-2,6-辛二烯-1-基(2E)-2-甲基-2-丁烯酸酯。它是一种具有香叶香气的化合物,分子式为C1...
1-环丁基哌嗪(CAS号:132800-13-6)安全吗?
1-环丁基哌嗪在适当的操作条件下是相对安全的,但如遇明火或高热会释放有毒气体。操作时应佩戴防护眼镜和手套,避免吸入或接触皮肤、眼睛。
来源期刊
Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.














