Stealth macromolecular platforms for the design of MRI blood pool contrast agents
文献信息
发布日期
2011-07-28
DOI
10.1039/C1PY00198A
影响因子
5.582
作者
Mathurin Grogna, Rudi Cloots, André Luxen, Christine Jérôme, Catherine Passirani, Nolwenn Lautram, Jean-F. Desreux, Mike Collodoro, Marie-Claire De Pauw-Gillet, Christophe Detrembleur
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摘要
Stealth macromolecular platforms bearing alkyne groups and poly(ethylene oxide) brushes were synthesized by reversible addition fragmentation chain transfer (RAFT) polymerization. The anchoring of Gd3+-chelates bearing an azide group was then carried out by the Huisgen 1,3-dipolar cycloaddition (“click”) reaction in mild conditions, leading to macrocontrast agents for MRI applications. The gadolinium complex is hidden in the PEO shell that renders the macrocontrast agents free of any cytotoxicity and stealth to proteins of the immune system. Relaxometry measurements have evidenced an improved relaxivity of the macrocontrast agent compared to ungrafted gadolinium chelate. Moreover, this relaxivity is further enhanced when the spacer length between the Gd3+-chelate and the polymer backbone is shorter, as the result of its decreased tumbling rate. These novel products are therefore promising candidates for MRI applications.
期刊推荐
Nature Reviews Drug Discovery
Photochemical & Photobiological Sciences
Mini-Reviews in Medicinal Chemistry
Molecular Diversity
Angewandte Chemie International Edition
Contact Lens & Anterior Eye
Journal of Medical Biochemistry
Green Chemistry
European Journal of Organic Chemistry
Environmental Toxicology and Pharmacology
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来源期刊
Polymer Chemistry
CiteScore:
8.6
自引率:
7.3%
年发文量:
457
Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.
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