Investigation into fiber formation in N-alkyl urea peptoid oligomers and the synthesis of a water-soluble PEG/N-alkyl urea peptoid oligomer conjugate

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发布日期 2011-08-30

DOI 10.1039/C1PY00284H

影响因子 5.582

作者

Xiaoping Chen, Keyang Ding, Neil Ayres

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摘要

The synthesis and self assembly of an N-alkyl urea peptoid oligomer/polymer conjugate that self-assembles into ribbon-like structures is reported. The aggregation of the N-alkyl urea peptoid oligomers has been investigated using NMR spectroscopy, with long and highly uniform fibers with micron dimensions observed in scanning electron microscopy images from both organo-soluble and water-soluble versions. The results of these studies indicate that hydrogen bonding likely is the major driving force for the self assembly. The oligomer was conjugated to poly(ethylene glycol) (PEG) producing a water soluble polymer/N-alkyl urea peptoid conjugate where the self-assembly of the N-alkyl urea peptoid was retained. These polymer conjugates represent a new approach to polymer biomimetic conjugates.

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Green Chemistry

Angewandte Chemie International Edition

Nature Reviews Drug Discovery

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Foundations of Chemistry

Photochemical & Photobiological Sciences

Molecular Diversity

Molecules

Journal of Enzyme inhibition and Medicinal Chemistry

Faraday Discussions

来源期刊

Polymer Chemistry

CiteScore: 8.6

自引率: 7.3%

年发文量: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Investigation into fiber formation in N-alkyl urea peptoid oligomers and the synthesis of a water-soluble PEG/N-alkyl urea peptoid oligomer conjugate

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