Biodegradable, pH-sensitive P(CL-Pluronic-CL-co-MAA-MEG) hydrogel for 5-aminosalicylic acid delivery

文献信息

发布日期 2012-03-28

DOI 10.1039/C2PY20086D

影响因子 5.582

作者

Ke Wang, Qiang Fu, WeiFeng Li, Yang Gao, JiYe Zhang

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摘要

In this paper, a series of biodegradable and pH-sensitive hydrogels from Pluronic, poly(ε-caprolactone) (PCL), and methylacrylic acid (MAA) polymer matrix was successfully prepared via UV-initiated free radical polymerization method. A scanning electron microscope was adopted to detect the internal microstructure of the prepared hydrogels at different pH values (pH 1.2 and pH 7.2). To investigate the pH-responsivity and hydrolytic degradation characterization of the hydrogel, detailed parameters including MAA and PCL polymers content, PEG content, BIS content and molecular weight of Pluronic have been employed in this work. The in vitro release behavior of hydrophobic 5-aminosalicylic acid drug was investigated in this paper, which indicated that this new kind of hydrogel with good pH-responsivity might have great potential applications in smart drug delivery systems, especially in colon targeting therapy.

期刊推荐

Chinese Journal of Chemistry

Critical Reviews in Solid State and Materials Sciences

Cellulose

Main Group Chemistry

Herald of the Russian Academy of Sciences

Biocatalysis and Biotransformation

NDT & E International

Journal of the Indian Institute of Science

Colloid Journal

Heteroatom Chemistry

来源期刊

Polymer Chemistry

CiteScore: 8.6

自引率: 7.3%

年发文量: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Biodegradable, pH-sensitive P(CL-Pluronic-CL-co-MAA-MEG) hydrogel for 5-aminosalicylic acid delivery

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