Biofunctional micellar nanoparticles from peptide-b-polymer chimeras

文献信息

发布日期 2013-01-07

DOI 10.1039/C2PY21044D

影响因子 5.582

作者

Anne-Laure Wirotius, Katell Bathany, Emmanuel Ibarboure, Olivia Condassamy, Sébastien Lecommandoux

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摘要

We describe the precision synthesis and characterization of amphiphilic peptide-b-polymer chimeras encoding, at the molecular level, self-assembly properties and biological functions, presently cell membrane penetrating motifs (Tat peptide). Self-assembled micellar nanoparticles obtained from a series of Tat-b-poly(trimethylene carbonate) (Tat-b-PTMC) chimeras with tunable hydrophilic fractions were finely characterized in order to establish chimera–nanoparticle structure relationships. Well-defined nanoparticles with diameters ranging from 22 to 40 nm could be obtained by direct self-assembly in buffer.

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来源期刊

Polymer Chemistry

CiteScore: 8.6

自引率: 7.3%

年发文量: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Biofunctional micellar nanoparticles from peptide-b-polymer chimeras

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期刊推荐

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Contents

Similarity between the kinetic parameters of the buffer-mediated proton exchange reaction of a xanthenic derivative in its ground- and excited-state

A crossed molecular beam study on the reaction of methylidyne radicals [CH(X2Π)] with acetylene [C2H2(X1Σg+)]—competing C3H2 + H and C3H + H2 channels

Manipulating the growth of aqueous semiconductor nanocrystals through amine-promoted kinetic process

On the role of mercury in the non-covalent stabilisation of consecutive U–HgII–U metal-mediated nucleic acid base pairs: metallophilic attraction enters the world of nucleic acids

Fast and ultrafast spectroscopic investigation of tetracycline derivatives in organic and aqueous media

Electron transfer dynamics across self-assembled N-(2-mercaptoethyl) octadecanamide/mycolic acid layers: impedimetric insights into the structural integrity and interaction with anti-mycolic acid antibodies

Structural characterization of metal–metal bonded polymer[Ru(L)(CO)2]n (L = 2,2′-bipyridine) in the solid state using high-resolution NMR and DFT chemical shift calculations

Interaction of water, hydrogen and their mixtures with SnO2 based materials: the role of surface hydroxyl groups in detection mechanisms

Enhancing the interactions between neutral molecular tweezers and anions

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来源期刊

Polymer Chemistry

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