A WS2 nanosheet-based platform for fluorescent DNA detection via PNA–DNA hybridization

文献信息

发布日期 2014-11-07

DOI 10.1039/C4AN01738B

影响因子 4.616

作者

Shuting Wang, Yulin Zhang, Yong Ning, Guo-Jun Zhang

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摘要

The WS2 nanosheet, a two-dimensional layered nanomaterial, shows high fluorescence quenching ability for the dye-labeled ssDNA. Currently, most of the fluorescent DNA detection methods employ DNA as a probe for recognition of target DNA. Peptide nucleic acid (PNA) is a DNA mimic but a neutral molecule, showing superior hybridization properties to target DNA. Based on the unique properties of WS2 nanosheet and PNA–DNA hybridization, we have developed a rapid, simple, stable and sensitive approach for DNA detection based on good fluorescence quenching ability of the WS2 nanosheet as well as high binding affinity and specificity of PNA to DNA. This novel assay is capable of exhibiting high sensitivity and specificity with a detection limit of 500 pM, and discriminating between single bases.

期刊推荐

Journal of Heterocyclic Chemistry

Russian Chemical Reviews

Journal of Catalysis

Science Progress

Fibre Chemistry

Helvetica Chimica Acta

Science

Journal of Organometallic Chemistry

Pharmacological Reviews

Proceedings of the National Academy of Sciences of the United States of America

来源期刊

Analyst

CiteScore: 7.8

自引率: 5.6%

年发文量: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

A WS2 nanosheet-based platform for fluorescent DNA detection via PNA–DNA hybridization

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