A tandem mass spectrometry-based method to assess the architectural purity of synthetic polymers: a case of a cyclic polylactide obtained by click chemistry

文献信息

发布日期 2014-08-29

DOI 10.1039/C4PY01087F

影响因子 5.582

作者

Philippe Dubois, Olivier Coulembier, Pascal Gerbaux, Antony Memboeuf

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摘要

A tandem mass spectrometry-based method is developed to determine the degree of purity achieved in the cyclization of a linear poly(L-lactide) prepared by copper-catalyzed alkyne-azide cycloaddition. When proton nuclear magnetic resonance, size-exclusion chromatography, and single-stage mass spectrometry are unable to demonstrate the presence of a residual linear polymer, the proposed ESI-tandem mass spectrometry methodology allows detection of starting material traces (<5%) based on radically different collision-induced dissociation (CID) behaviours. The technique is believed to be readily adaptable to numerous isomeric pairs of macromolecules presenting different CID characteristics.

期刊推荐

Annual Review of Public Health

Tetrahedron

Journal of Dispersion Science and Technology

Drug and Chemical Toxicology

Crystal Research and Technology

Bioorganic Chemistry

Pharmacology & Therapeutics

Organic Geochemistry

Applied Clay Science

European Journal of Medicinal Chemistry

来源期刊

Polymer Chemistry

CiteScore: 8.6

自引率: 7.3%

年发文量: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

A tandem mass spectrometry-based method to assess the architectural purity of synthetic polymers: a case of a cyclic polylactide obtained by click chemistry

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