Noninvasive theranostic imaging of HSV-TK/GCV suicide gene therapy in liver cancer by folate-targeted quantum dot-based liposomes

文献信息

发布日期 2015-04-10
DOI 10.1039/C5BM00077G
影响因子 6.843
作者

Dan Shao, Jing Li, Yue Pan, Xin Zhang, Xiao Zheng, Zheng Wang, Ming Zhang, Hong Zhang


查看原文

摘要

Theranostics is emerging as a popular strategy for cancer therapy; thanks to the development of nanotechnology. In this work, we have combined an HSV-TK/GCV suicide gene system and near-infrared quantum dots, as the former is quite effective in liver cancer treatment and the latter facilitates tumor imaging. A folate-modified theranostic liposome (FL/QD-TK) was developed, which is composed of an HSV-TK suicide gene covalently coupling with near-infrared fluorescent CdSeTe/ZnS core/shell quantum dots. The liver cancer-targeting and biosafety of FL/QD-TK were studied in vitro and in vivo. FL/QD-TK exhibited highly specific tumor imaging and strong inhibition of the folate receptor-overexpressed Bel-7402 mouse xenografts without systematic toxicity. This study may shed light on gene delivery and targeted cancer therapy.

相关文献

Theoretical studies on the transport mechanism of 5-fluorouracil through cyclic peptide based nanotubes

Sofie Van Damme, Patrick Bultinck, Venkatesan Subramanian

2012-10-23 Paper

DOI: 10.1039/C2CP42038D

New insight into the ZnO sulfidation reaction: mechanism and kinetics modeling of the ZnS outward growth

David Chiche, Javier Pérez-Pellitero, Loïc Favergeon, Anne-Sophie Gay, Michèle Pijolat

2012-12-13 Paper

DOI: 10.1039/C2CP42988H

Single-crystal adsorptioncalorimetry and density functional theory of CO chemisorption on fcc Co{110}

Kristine Liao, Vittorio Fiorin, David S. D. Gunn, Stephen J. Jenkins, David A. King

2013-02-13 Paper

DOI: 10.1039/C3CP43836H

Naphthalene bisimides asymmetrically and symmetrically N-substituted with triarylamine – comparison of spectroscopic, electrochemical, electronic and self-assembly properties

Renata Rybakiewicz, David Djurado, Robert Nowakowski, Petr Toman, Jiri Pfleger, Jean-Marie Verilhac, Malgorzata Zagorska, Adam Pron

2012-12-14 Paper

DOI: 10.1039/C2CP43505E

Anchoring sites to the STM tip can explain multiple peaks in single molecule conductance histograms

S. Alexis Paz, Martin E. Zoloff Michoff, Christian F. A. Negre, Jimena A. Olmos-Asar, Marcelo M. Mariscal, Cristián G. Sánchez, Ezequiel P. M. Leiva

2012-11-22 Paper

DOI: 10.1039/C2CP43811A

Ultrafast dynamics in iron tetracarbonyl olefin complexes investigated with two-dimensional vibrational spectroscopy

Matthijs R. Panman, Arthur C. Newton, Jannie Vos, Bart van den Bosch, Vladica Bocokić, Joost N. H. Reek, Sander Woutersen

2012-11-27 Paper

DOI: 10.1039/C2CP43565A

Sophorolipids-functionalized iron oxide nanoparticles

Lorenzo Stievano, Inge Van Bogaert

2012-12-17 Paper

DOI: 10.1039/C2CP41977G

A critical perspective on molecular electronic junctions: there is plenty of room in the middle

Haijun Yan, Adam Johan Bergren

2012-11-21 Perspective

DOI: 10.1039/C2CP43516K

您可能还喜欢

化合物问答

4-((4-甲基哌嗪-1-基)甲基)苯硼酸(CAS号:763120-62-3)的市场或研究趋势如何?

随着有机硼化学的发展,该化合物在催化、药物合成、材料科学等领域展现出潜在的应用价值。近年来,其在药物前体合成中的应用越来越受到关注。市场趋势显示,随着科研投入的...

763120-62-3{4-[(4-Methyl-1-pipe...
化合物问答

如何储存2,4,5-三甲基-1-硝基苯(CAS号:610-91-3)?

2,4,5-三甲基-1-硝基苯应储存在阴凉、干燥且通风良好的地方,避免阳光直射。储存在密封的金属容器中,远离火源和热源。储存温度应控制在25°C以下,湿度不宜过...

610-91-31,2,4-Trimethyl-5-ni...
化合物问答

处理2,5-二碘噻吩(CAS号:625-88-7)时应注意哪些实验室安全事项?

在处理2,5-二碘噻吩时,应穿戴适当的个人防护装备(PPE),包括实验室外套、手套和防护眼镜。在通风橱中进行操作以避免吸入蒸气。如果发生泄漏,应立即疏散人员并使...

625-88-72,5-Diiodothiophene
化合物问答

在合成中是否有6-bromo-3-chloro-1H-indole(CAS号:57916-08-2)的替代品?

在合成6-溴-3-氯-1H-吲哚(CAS号:57916-08-2)时,可以考虑使用一些类似的化合物作为替代品,如6-氯-3-氯-1H-吲哚或3-氯-1H-吲哚,...

57916-08-26-bromo-3-chloro-1H-...
化合物问答

在合成中是否有(R)-(-)-1-(1-萘基)乙基异氰酸酯(CAS号:42340-98-7)的替代品?

可以考虑使用类似结构的化合物,如1-[(1R)-1-(2-氨基乙基)萘-1-基]乙基异氰酸酯作为替代品。此外,还可以寻找其他类型的异氰酸酯衍生物,如苯基异氰酸酯...

42340-98-71-[(1R)-1-Isocyanato...
化合物问答

3-氨基苯甲酰苯胺(CAS号:14315-16-3)适用哪些法规指南?

3-氨基苯甲酰苯胺适用于多项法规指南,包括但不限于GHS(全球化学品统一分类和标签制度)分类为皮肤腐蚀/刺激类别2,以及潜在的皮肤过敏性类别1。在欧盟地区,它受...

14315-16-33-Amino-N-phenylbenz...
化合物问答

β-环柠檬醛-D5(CAS号:26309-95-5)通常如何合成?

β-环柠檬醛-D5可通过不对称合成方法获得。常见的合成路线包括以环己酮为原料,经过选择性氧化、还原、保护基引入等步骤,最终得到目标化合物。该合成过程中通常使用多...

26309-95-5[(2,2-Dimethylpropan...
化合物问答

如何储存布尼洛尔(CAS号:34915-68-9)?

布尼洛尔应存放在阴凉干燥处,避免阳光直射和高温。建议储存温度在15-30摄氏度之间,远离儿童触及范围。

34915-68-9Bunitrolol
化合物问答

如何处理含有BIO-1211(CAS号:187735-94-0)的废料?

对于含有BIO-1211(CAS号:187735-94-0)的废料,首先应进行分类收集,确保符合环保要求。然后,可以考虑通过焚烧或其他专业处理方法进行处置。在处...

187735-94-0BIO-1211
化合物问答

如何处理含有4-氯-2-氟-3-甲基苯酚(CAS号:1351668-24-0)的废料?

含有该化合物的废液应收集至专用容器中,避免与其他化学品混合。可采用焚烧或送交专业废弃物处理公司处理。处理过程中需遵守当地环保法规,确保不产生二次污染。处理前应进...

1351668-24-04-Chloro-2-fluoro-3-...

来源期刊

Biomaterials Science

Biomaterials Science
CiteScore: 11.5
自引率: 3.4%
年发文量: 492

Biomaterials Science is an international high impact journal exploring the science of biomaterials and their translation towards clinical use. Its scope encompasses new concepts in biomaterials design, studies into the interaction of biomaterials with the body, and the use of materials to answer fundamental biological questions. Papers do not necessarily need to report a new biomaterial but should provide novel insight into the biological applications of the biomaterial. Articles that primarily focus on demonstrating novel materials chemistry and bring a molecular picture to bear on a given material’s suitability as a biomaterial are more suited to our companion journal, Journal of Materials Chemistry B. Biomaterials Science publishes primary research and review-type articles in the following areas: molecular design of biomaterials, including translation of emerging chemistries to biomaterials science of cells and materials at the nanoscale and microscale materials as model systems for stem cell and human biology materials for tissue engineering and regenerative medicine (Nano)materials and (nano)systems for therapeutic delivery interactions at the biointerface biologically inspired and biomimetic materials, including bio-inspired self-assembly systems and cell-inspired synthetic tools next-generation biomaterials tools and methods

推荐化合物

推荐供应商

免责声明
本页面提供的学术期刊信息仅供参考和研究使用。我们与任何期刊出版商均无关联,也不处理投稿事宜。如有投稿相关咨询,请直接联系相关期刊出版商。
如发现页面信息有误,请发送邮件至 support@chemtradehub.com 联系我们。我们将及时核实并处理您的问题。