Titanium dioxide nanoparticles alter cellular morphology via disturbing the microtubule dynamics

文献信息

发布日期 2015-04-03
DOI 10.1039/C5NR01448D
影响因子 7.79
作者

Qiusha Tang


查看原文

摘要

Titanium dioxide (TiO2) nanoparticles (NPs) have been widely used in our daily lives, for example, in the areas of sunscreens, cosmetics, toothpastes, food products, and nanomedical reagents. Recently, increasing concern has been raised about their neurotoxicity, but the mechanisms underlying such toxic effects are still unknown. In this work, we employed a human neuroblastoma cell line (SH-SY5Y) to study the effects of TiO2 NPs on neurological systems. Our results showed that TiO2 NPs did not affect cell viability but induced noticeable morphological changes until 100 μg ml−1. Immunofluorescence detection showed disorder, disruption, retraction, and decreased intensity of the microtubules after TiO2 NPs treatment. Both α and β tubule expressions did not change in the TiO2 NP-treated group, but the percentage of soluble tubules was increased. A microtubule dynamic study in living cells indicated that TiO2 NPs caused a lower growth rate and a higher shortening rate of microtubules as well as shortened lifetimes of de novo microtubules. TiO2 NPs did not cause changes in the expression and phosphorylation state of tau proteins, but a tau–TiO2 NP interaction was observed. TiO2 NPs could interact with tubule heterodimers, microtubules and tau proteins, which led to the instability of microtubules, thus contributing to the neurotoxicity of TiO2 NPs.

相关文献

A cavitand with a fluorous rim acts as an amine receptor

Richard J. Hooley, Per Restorp, Julius Rebek Jr

2008-11-06 Communication

DOI: 10.1039/B814069C

Photoinitiated polymerisation of monolithic stationary phases in polyimide coated capillaries using visible region LEDs

Zarah Walsh, Silvija Abele, Brian Lawless, Dominik Heger, Petr Klán, Michael C. Breadmore, Brett Paull, Mirek Macka

2008-11-07 Communication

DOI: 10.1039/B816958F

Front cover

Cover

DOI: 10.1039/B819949N

Aqueous dispersions of TCNQ-anion-stabilized graphene sheets

Rui Hao, Wen Qian, Luhui Zhang, Yanglong Hou

2008-11-12 Communication

DOI: 10.1039/B816971C

Azaarene cis-dihydrodiol-derived 2,2′-bipyridine ligands for asymmetric allylic oxidation and cyclopropanation

Derek R. Boyd, Narain D. Sharma, Lenuta Sbircea, Deirdre Murphy, Tayeb Belhocine, John F. Malone, Stuart L. James, Christopher C. R. Allen

2008-10-09 Communication

DOI: 10.1039/B814678K

Supported ATRP of fluorinated methacrylates in supercritical carbon dioxide: preparation of scCO2 soluble polymers with low catalytic residues

Bruno Grignard, Cédric Calberg, Christine Jérôme, Wenxin Wang, Steven Howdle, Christophe Detrembleur

2008-10-01 Communication

DOI: 10.1039/B812297K

A snapshot of a coordination polymerself-assembly process: the crystallization of a metastable 3D network followed by the spontaneous transformation in water to a 2D pseudopolymorphic phase

Thierry Bataille, Ferdinando Costantino, Andrea Ienco, Annalisa Guerri, Fabio Marmottini, Stefano Midollini

2008-11-04 Communication

DOI: 10.1039/B813222D

Synthesis of tri- and tetraynes using a butadiynyl synthon

Khalid Azyat, Eike Jahnke, Trent Rankin, Rik R. Tykwinski

2008-11-13 Communication

DOI: 10.1039/B816177A

Thermal cyclotrimerization of tetraphenyl[5]cumulene(tetraphenylhexapentaene) to a tricyclodecadiene derivative

Nazrul Islam, Takashi Ooi, Tetsuo Iwasawa, Masaki Nishiuchi, Yasuhiko Kawamura

2008-12-15 Communication

DOI: 10.1039/B815620D

Morphological changes in the self-assembly of a radial oligo-phenylene ethynylene amphiphilic system

Gustavo Fernández, Fátima García, Luis Sánchez

2008-11-12 Communication

DOI: 10.1039/B818378C

您可能还喜欢

化合物问答

4-[4-三氟甲基苯基]恶唑(CAS号:1126636-40-5)通常如何合成?

4-[4-三氟甲基苯基]恶唑通常通过将4-三氟甲基苯酚与异硫氰酸苯酯在有机溶剂中进行酯化反应合成。该反应可在无水条件下,使用适当的催化剂,如四丁基氢氧化铵,以提...

1126636-40-54-(4-(Trifluoromethy...
化合物问答

氢溴酸西酞普兰(CAS号:59729-32-7)的主要用途是什么?

氢溴酸西酞普兰主要用于治疗抑郁症,通过调节大脑中的神经递质平衡来改善情绪。

59729-32-71-[3-(Dimethylamino)...
化合物问答

RockPhos Pd G3(CAS号:2009020-38-4)通常如何合成?

RockPhos Pd G3 通常通过钯催化偶联反应合成,使用配体 (2'-Amino-2-biphenylyl)(methanesulfonato-kappa...

2009020-38-4(2'-Amino-2-biphenyl...
化合物问答

1-哌啶甲酰胺(CAS号:2158-03-4)的市场或研究趋势如何?

1-哌啶甲酰胺作为有机合成中的重要中间体,其市场需求主要受医药、农药、染料等行业推动。近年来,随着新药开发和绿色化学的发展,该化合物的研究趋势集中在开发更高效、...

2158-03-41-Piperidinecarboxam...
化合物问答

2-(二苯基膦基)乙胺(CAS号:4848-43-5)适用哪些法规指南?

2-(二苯基膦基)乙胺适用于多种法规指南,包括但不限于《全球化学品统一分类和标签制度》(GHS),欧盟《化学品注册、评估、授权和限制》法规(REACH),以及美...

4848-43-52-(Diphenylphosphino...
化合物问答

如何储存间苯二甲酸二烯丙酯(CAS号:1087-21-4)?

间苯二甲酸二烯丙酯应储存在阴凉、干燥、通风良好的地方,远离火源和热源。储存容器应密封,避免光照和高温。储存温度应控制在25℃以下,相对湿度应低于80%。避免与其...

1087-21-4Diallyl isophthalate
化合物问答

什么是间甲苯异硫代异氰酸酯(CAS号:621-30-7)?

间甲苯异硫代异氰酸酯是一种有机化合物,分子式为C7H7NO2S,具有刺激性气味。它是一种重要的有机合成中间体,在合成其他化合物时广泛应用。

621-30-71-Isothiocyanato-3-m...
化合物问答

在合成中是否有N-Boc-D-苯丙氨醇(CAS号:106454-69-7)的替代品?

在合成中,可以考虑使用N-Cbz-D-苯丙氨醇或N-Fmoc-D-苯丙氨醇作为替代品。这些化合物同样具有保护氨基的功能,且在合成过程中表现出良好的反应性能。

106454-69-72-Methyl-2-propanyl ...
化合物问答

3-羟甲基-2-氧异丙基吡啶(CAS号:954240-50-7)的主要用途是什么?

3-羟甲基-2-氧异丙基吡啶主要用于有机合成领域,可以作为合成其他药物、农药或精细化学品的中间体。此外,它还可能在实验室研究中作为特定反应的前体或溶剂。

954240-50-7(2-Isopropoxy-3-pyri...
化合物问答

6-氨基-9-甲基嘌呤(CAS号:700-00-5)应用于哪些行业?

6-氨基-9-甲基嘌呤目前主要应用于医药行业,作为某些药物的中间体。此外,它还可能用于聚合物、传感器和半导体的某些领域,作为功能性单体或掺杂剂。

700-00-59-Methyl-9H-purin-6-...

来源期刊

Nanoscale

Nanoscale
CiteScore: 12.1
自引率: 5.2%
年发文量: 1681

Nanoscale is a high-impact international journal, publishing high-quality research across nanoscience and nanotechnology. Nanoscale publishes a full mix of research articles on experimental and theoretical work, including reviews, communications, and full papers. Highly interdisciplinary, Nanoscale appeals to scientists, researchers and professionals interested in nanoscience and nanotechnology, quantum materials and quantum technology, including the areas of physics, chemistry, biology, medicine, materials, energy/environment, information technology, detection science, healthcare and drug discovery, and electronics. For publication in Nanoscale, papers must report high-quality reproducible new work that will be of significant general interest to the journal's wide international readership. Nanoscale is a collaborative venture between the Royal Society of Chemistry Publishing and a leading nanoscience research centre, the National Center for Nanoscience and Technology (NCNST) in Beijing, China. image block The journal publishes weekly issues, complementing and building on the nano content already published across the Royal Society of Chemistry Publishing journal portfolio. Since its launch in late 2009, Nanoscale has established itself as a platform for high-quality, cross-community research that bridges the various disciplines involved with nanoscience and nanotechnology, publishing important research from leading international research groups.

推荐化合物

推荐供应商

免责声明
本页面提供的学术期刊信息仅供参考和研究使用。我们与任何期刊出版商均无关联,也不处理投稿事宜。如有投稿相关咨询,请直接联系相关期刊出版商。
如发现页面信息有误,请发送邮件至 support@chemtradehub.com 联系我们。我们将及时核实并处理您的问题。