Graphene oxide complex as a pH-sensitive antitumor drug

文献信息

发布日期 2015-01-29

DOI 10.1039/C5PY00047E

影响因子 5.582

作者

Rumei Cheng, Ruitao Zou, Shengju Ou, Rui Guo, Ruiying Yan, Haiyan Shi, Shanshan Yu, Xiaojian Li, Yexu Bu, Mimi Lin, Yong Liu

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摘要

A pH-sensitive, nanostructured antitumor drug, GO-CONH-Schiff base (GCS), was prepared from the chitosan-xanthone Schiff base (CS)-modified graphene oxide (GO) complex. The successful synthesis of GCS was confirmed using various spectroscopic techniques, including FT-IR, XPS, UV-vis and TGA. The resulting GCS showed superb antitumor activity with the pH-sensitive release of the antitumor part, CS, and decreased cytotoxicity of GCS to normal human cells. The release of CS was stable and thorough in the solution at pH 1 (the pH value for gastric juice), suggesting that the as-synthesized, pH-sensitive drug could provide new insights into the design of advanced nanostructured oral drugs.

期刊推荐

Annual Review of Public Health

European Journal of Medicinal Chemistry

Applied Clay Science

Progress in Materials Science

Journal of Natural Products

Crystal Research and Technology

Journal of Dispersion Science and Technology

Bioorganic Chemistry

Dyes and Pigments

Pharmacology & Therapeutics

来源期刊

Polymer Chemistry

CiteScore: 8.6

自引率: 7.3%

年发文量: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Graphene oxide complex as a pH-sensitive antitumor drug

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期刊推荐

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Polymer Chemistry

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