A new pathway towards polymer modified cellulose nanocrystals via a “grafting onto” process for drug delivery
文献信息
发布日期
2015-04-17
DOI
10.1039/C5PY00466G
影响因子
5.582
作者
Hairong Wang, Jinlin He, Mingzu Zhang, Kam Chiu Tam, Peihong Ni
查看原文
摘要
Poly(ethyl ethylene phosphate) (PEEP) modified cellulose nanocrystals (CNCs) (CNC-g-PEEP) were synthesized through a “grafting onto” process, in which a combination of ring-opening polymerization (ROP) and Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC) “click” chemistry was utilized. The resulting suspension of negatively-charged CNC-g-PEEP nanocrystals could be used to encapsulate doxorubicin (DOX) by electrostatic interactions and release the drug in the tumor cell environment.
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来源期刊
Polymer Chemistry
CiteScore:
8.6
自引率:
7.3%
年发文量:
457
Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.
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