A library of heptyl mannose-functionalized copolymers with distinct compositions, microstructures and neighboring non-sugar motifs as potent antiadhesives of type 1 piliated E. coli

文献信息

发布日期 2016-03-16

DOI 10.1039/C6PY00118A

影响因子 5.582

作者

Sébastien G. Gouin, Julie Bouckaert

查看原文

摘要

A large library of mannosylated copolymers having tunable compositions, microstructures and pendant motifs neighboring mannose of distinct nature were synthesized by combining (i) sequential, batch or semi-batch RAFT (co)polymerizations of glycidyl methacrylate (GMA) and N-[7-(α-D-mannopyranosyloxy)heptyl] methacrylamide (HMM) and (ii) epoxy-amine post-modifications with ethanolamine, (2-aminoethyl)trimethylammonium chloride or taurine. Examination of the anti-adhesive properties against type 1 piliated E. coli allowed for identifying copolymers among the three series of post-modified glycopolymers capable of efficiently inhibiting bacterial adhesion at 0.1 and 1 μM (on a mannose unit basis) in pre and post-incubation adhesion assays respectively.

期刊推荐

Physical Chemistry Chemical Physics

Journal of Enzyme inhibition and Medicinal Chemistry

Coloration Technology

Journal of Medical Biochemistry

Contact Lens & Anterior Eye

Mini-Reviews in Medicinal Chemistry

Nature Reviews Drug Discovery

CrystEngComm

Angewandte Chemie International Edition

Green Chemistry

来源期刊

Polymer Chemistry

CiteScore: 8.6

自引率: 7.3%

年发文量: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

A library of heptyl mannose-functionalized copolymers with distinct compositions, microstructures and neighboring non-sugar motifs as potent antiadhesives of type 1 piliated E. coli

文献信息

期刊推荐

相关文献

An aptamer triple helix molecular switch for sensitive electrochemical assay of lipocalin 1 biomarker via dual signal amplifications

Smartphone-based microplate reader for high-throughput quantitation of disease markers in serum

Droplet microfluidics for CTC-based liquid biopsy: a review

Front cover

A regenerable electrochemical sensor for electro-inactive cyclovirobuxine D detection in biological samples

Contents list

Reflective epoxy resin/chitosan/PAA composite-functionalized fiber-optic interferometric probe sensor for sensitive heavy metal ion detection

Solvent-regulated fluorescence off–on signaling of Ni(ii) and Zn(ii) with the formation of two mononuclear complexes with an ATP detection ability by Zn(ii) assembly

Volatile metabolites differentiate air–liquid interface cultures after infection with Staphylococcus aureus

Insight into the role of nitrogen in N-doped ordered mesoporous carbons for the spontaneous non-covalent attachment and electrografting of redox-active materials

您可能还喜欢

如何储存1,2-环己二酮环乙缩醛(CAS号：4746-96-7)？

Ecopladib(CAS号：381683-92-7)的市场或研究趋势如何？

2,3-Dimethyl-3H-imidazo[4,5-c]pyridine(CAS号：52538-09-7)通常如何合成？

2,3,4,5-tetrahydro-1H-3-苯并氮杂环;盐酸盐(CAS号：17379-01-0)的市场或研究趋势如何？

解草嗪(CAS号：68-90-6)安全吗？

如何储存盐酸甘氨酸丁酯(CAS号：13048-99-2)？

什么是2-Iodo-N,N-dimethylbenzamide(CAS号：54616-46-5)？

如何储存2-氨基-N-环己基乙酰胺(CAS号：16817-90-6)？

5-溴-2-(4H-1,2,4-三唑-4-基)吡啶(CAS号：959240-99-4)的市场或研究趋势如何？

2,4-二溴-6-三氟甲基嘧啶(CAS号：785778-00-9)通常如何合成？

来源期刊

Polymer Chemistry

推荐化合物

1-(1,3-Thiazol-4-yl)ethanamine

N-[2-(4-Hydroxyphenoxy)-4-nitrophenyl]methanesulfonamide

6-(2-Methylphenyl)-2-pyridinecarboxylic acid

2,2-dideuterio-2-(3,4,5,6-tetradeuterio-2-pyridyl)acetic acid;hydrochloride

2,2',3,3',4,5,5',6,6'-Nonabromobiphenyl

推荐供应商