I2 catalyzed access of spiro[indoline-3,4′-pyridine] appended amine dyad: new ON–OFF chemosensors for Cu2+ and imaging in living cells
文献信息
Animesh Mondal, Barnali Naskar, Sanchita Goswami, Chandraday Prodhan, Keya Chaudhuri, Chhanda Mukhopadhyay
An easy access to an amine-appended spiro[indoline-3,4′-pyridine] ON–OFF chemosensor by a one-pot four-component reaction using commercially available and an environmentally benign catalytic amount of molecular I2 (10 mol%) in aqueous ethanol at ambient temperature is described. The generated system could be utilized for the selective detection of Cu2+ as it demonstrated a colorimetric naked eye change along with an ON–OFF fluorescence response towards Cu2+ at physiological pH. The sensors exhibited high selectivity for Cu2+ over other common cations with detection limit in the range of 10−7 (M). Notably, this is the first report of a spiro[indoline-3,4′-pyridine] moiety acting as a sensor for Cu2+via a on–off fluorescence response. In addition, the probe system was successfully applied for imaging Cu2+ in human hepatocellular liver carcinoma cells (HepG2), demonstrating a new avenue for molecular imaging and biomedical applications.
期刊推荐

Russian Chemical Bulletin

Saudi Pharmaceutical Journal

Russian Journal of Applied Chemistry

Chemical Communications

Journal of Saudi Chemical Society

Russian Journal of Bioorganic Chemistry

Organic Process Research & Development

Chemistry Education Research and Practice

Crystallography Reports

Drug Discovery Today
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Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.


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