Bioluminescent probe for detecting endogenous hypochlorite in living mice
文献信息
Chunchao Tang, Yuqi Gao, Tingting Liu, Yuxing Lin, Xiaomeng Zhang, Chaochao Zhang, Xiang Li, Tianchao Zhang, Lupei Du
As a kind of biologically important reactive oxygen species (ROS), hypochlorite (ClO−) plays a crucial role in many physiological processes. As such, endogenous ClO− is a powerful antibacterial agent during pathogen invasion. Nonetheless, excessive endogenous ClO− could pose a health threat to mammalian animals including humans. However, the detection of endogenous ClO− by bioluminescence probes in vivo remains a considerable challenge. Herein, based on a caged strategy, we developed a turn-on bioluminescent probe 1 for the highly selective detection of ClO−in vitro and imaging endogenous ClO− in a mouse inflammation model. We anticipate that such a probe could help us understand the role of endogenous ClO− in a variety of physiological and pathological processes.
期刊推荐

Russian Journal of Bioorganic Chemistry

Saudi Pharmaceutical Journal

Organic Process Research & Development

Russian Journal of Coordination Chemistry

Current Opinion in Solid State & Materials Science

Chemical Communications

Russian Journal of Organic Chemistry

Journal of Natural Medicines

Russian Journal of Applied Chemistry

Current Opinion in Colloid & Interface Science
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Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.




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