One-pot preparation of polylactic acid-ibuprofen conjugates and their performance characterization
文献信息
发布日期
2017-10-24
DOI
10.1039/C7PY01213F
影响因子
5.582
作者
Liang Cao, Qun-Fang Wang, Zhi-Feng Hao, Le Jing, Zhao-Yang Wang
查看原文
摘要
A series of polylactic acid-ibuprofen (PLA-IBU) conjugates was directly synthesized via melt polycondensation of lactic acid (LA) with ibuprofen (IBU) in the presence of 0.3 wt% SnO at 160 °C for 6 h. The structures of the PLA-IBU conjugates were confirmed by FTIR and 1H NMR. According to the GPC and DSC results, the molecular weight and Tg of the PLA-IBUs with different feed ratios increase as the feed amount of LA increases. The drug content of these IBU-conjugated biodegradable polymers can also be simply controlled by adjusting the monomer feed ratio to reach the expected levels. The preliminary biological tests show that the PLA-IBU conjugates have the anticipated pharmaceutical activity, which is beneficial for these PLA-based IBU prodrugs prepared by this convenient one-pot method to be efficiently used in the biochemical and pharmaceutical industry.
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来源期刊
Polymer Chemistry
CiteScore:
8.6
自引率:
7.3%
年发文量:
457
Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.
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