Entry of nanoparticles into cells: the importance of nanoparticle properties
文献信息
发布日期
2017-12-18
DOI
10.1039/C7PY01603D
影响因子
5.582
作者
查看原文
摘要
Knowledge of the interactions between nanoparticles (NPs) and cell membranes is of great importance for the design of safe and efficient nanomedicines. Extensive studies aimed at understanding the correlation of NP properties with endocytosis have been carried out in the past few years. Here, we review the recent progress of these studies and provide an overview of the current state of knowledge on the influence of NP size, shape, stiffness and surface chemistry on cellular uptake. Special attention was dedicated to the uptake of non-spherical nanoparticles. Some general principles obtained from these fundamental studies will serve as guidelines for the design of optimised NP for enhanced cellular uptake. Finally, the opportunities for polymer chemists are discussed.
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来源期刊
Polymer Chemistry
CiteScore:
8.6
自引率:
7.3%
年发文量:
457
Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.
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