Copper-catalyzed aerobic oxidative coupling of ketones with P(O)–H compounds leading to β-ketophosphine oxides

文献信息

发布日期 2017-04-17

DOI 10.1039/C7QO00202E

影响因子 5.281

作者

Qiang Zhang, Jianxin Ji, Wei Wei

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摘要

A facile and efficient copper-catalyzed one-pot method for the construction of β-ketophosphine oxides has been developed via aerobic oxidative coupling of various ketones with P(O)–H compounds assisted by TBSOTf (t-butyldimethylsilyl triflate). Through this methodology, a series of β-ketophosphine oxides can be easily obtained in moderate to good yields with favorable functional group tolerance under very mild conditions. Isotope-labeling experiments suggested that the carbonyl oxygen atom of β-ketophosphine oxides originated from dioxygen.

期刊推荐

Polycyclic Aromatic Compounds

Herald of the Russian Academy of Sciences

Chinese Journal of Chemistry

Heteroatom Chemistry

Medicinal Chemistry Research

NDT & E International

Journal of Chemical Sciences

Critical Reviews in Solid State and Materials Sciences

Journal of the Indian Institute of Science

Electroanalysis

来源期刊

Organic Chemistry Frontiers

CiteScore: 7.8

自引率: 8.7%

年发文量: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Copper-catalyzed aerobic oxidative coupling of ketones with P(O)–H compounds leading to β-ketophosphine oxides

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