The growing role of structural mass spectrometry in the discovery and development of therapeutic antibodies

文献信息

发布日期 2018-04-30

DOI 10.1039/C8AN00295A

影响因子 4.616

作者

Yuwei Tian, Brandon T. Ruotolo

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摘要

The comprehensive structural characterization of therapeutic antibodies is of critical importance for the successful discovery and development of such biopharmaceuticals, yet poses many challenges to modern measurement science. Mass spectrometry has evolved into a rapid and sensitive tool for assessing the structures, stabilities, and dynamics of such proteins. Here, we review the current state-of-the-art mass spectrometry technologies focusing on the characterization of antibody-based therapeutics. We conclude by discussing the future of structural mass spectrometry, and its role in enabling the biopharmaceutical pipeline.

期刊推荐

Molecular Pharmacology

Planta Medica

Journal of Medicinal Chemistry

Israel Journal of Chemistry

Pure and Applied Chemistry

Helvetica Chimica Acta

Proceedings of the National Academy of Sciences of the United States of America

Journal of Organometallic Chemistry

Pharmacological Reviews

Organic Preparations and Procedures International

来源期刊

Analyst

CiteScore: 7.8

自引率: 5.6%

年发文量: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

The growing role of structural mass spectrometry in the discovery and development of therapeutic antibodies

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