Palladium mediated deallylation in fully aqueous conditions for native chemical ligation at aspartic and glutamic acid sites
文献信息
Muhammad Jbara, Emad Eid, Ashraf Brik
An efficient native chemical ligation approach at Asp and Glu sites is reported applying a hydrazide precursor, as a peptide thioester, and allyl protection at the side chain of Asp and Glu. The allyl protection was efficiently removed, after the ligation step, using the water-soluble palladium complex [Pd(allyl)Cl]2 and glutathione within a few minutes under fully aqueous conditions.
期刊推荐

Critical Reviews in Solid State and Materials Sciences

Herald of the Russian Academy of Sciences

Acta Metallurgica Sinica-English Letters

Journal of the Indian Institute of Science

Main Group Chemistry

Journal of Chemical Sciences

Atomization and Sprays

Bioorganic & Medicinal Chemistry

NDT & E International

Topics in Catalysis
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来源期刊
Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.


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