Iridium-catalyzed arylation of sulfoxonium ylides and arylboronic acids: a straightforward preparation of α-aryl ketones

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发布日期 2020-05-27

DOI 10.1039/D0QO00543F

影响因子 5.281

作者

Zi-Xuan Shen, Tong Che, Mei Zhong, Jia-Lin Song, Hua-Jie Kang, Hui Xie

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摘要

A highly efficient iridium(III)-catalyzed arylation coupling of sulfoxonium ylides with arylboronic acids to generate α-aryl ketones has been established for the first time. This protocol proceeded under redox-neutral conditions with a wide substrate scope (56 examples, up to 98% yield), high functional group compatibility, easily accessible starting materials and suitability for late-stage modification of structurally complex drug compounds. Further synthetic applications and elaboration of the product were also accomplished.

期刊推荐

Proceedings of the National Academy of Sciences of the United States of America

Molecular Pharmacology

Organic Preparations and Procedures International

European Journal of Wood and Wood Products

Journal of Heterocyclic Chemistry

Russian Chemical Reviews

Science

Planta Medica

Journal of Physics and Chemistry of Solids

Science Progress

来源期刊

Organic Chemistry Frontiers

CiteScore: 7.8

自引率: 8.7%

年发文量: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Iridium-catalyzed arylation of sulfoxonium ylides and arylboronic acids: a straightforward preparation of α-aryl ketones

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