Robust synthesis of C-terminal cysteine-containing peptide acids through a peptide hydrazide-based strategy
文献信息
Bing-Jia Yan, Han-Ying Zhu, Wei-Wei Shi, Tong-Kuai Xi, Jing Shi, Ge-Min Fang
A new robust strategy was reported for the epimerization-free synthesis of C-terminal Cys-containing peptide acids through mercaptoethanol-mediated hydrolysis of peptide thioesters prepared in situ from peptide hydrazides. This simple-to-operate and highly efficient method avoids the use of derivatization reagents for resin modification, thus providing a practical avenue for the preparation of C-terminal Cys-containing peptide acids.
期刊推荐

Organic Process Research & Development

Russian Journal of Coordination Chemistry

Russian Chemical Bulletin

Saudi Pharmaceutical Journal

Chemical Communications

Chemistry Education Research and Practice

Russian Journal of Applied Chemistry

Russian Journal of Organic Chemistry

Russian Journal of General Chemistry

Acta Materialia
相关文献
Dewetting acrylic polymer films with water/propylene carbonate/surfactant mixtures – implications for cultural heritage conservation
M. Baglioni, C. Montis, F. Brandi, T. Guaragnone, I. Meazzini, P. Baglioni, D. Berti
DOI: 10.1039/C7CP02608K
Catalytic mechanism of phenylacetone monooxygenases for non-native linear substrates
Miguel de Abreu, Lyndsey J. Ferguson, Derek J. Quinn, Thomas S. Moody, Meilan Huang
DOI: 10.1039/C7CP03640J
Nanodots of transition metal dichalcogenides embedded in MoS2 and MoSe2: first-principles calculations
Roberto Hiroki Miwa, Wanderlã L. Scopel, Everson S. Souza, José Eduardo Padilha, Adalberto Fazzio
DOI: 10.1039/C7CP03761A
Self-assembly of a nanotube from a black phosphorus nanoribbon on a string of fullerenes at low temperature
Jiao Shi, Ling-Nan Liu, Qing-Hua Qin
DOI: 10.1039/C7CP04427E
Beta transmutations in apatites with ferric iron as an electron acceptor – implication for nuclear waste form development
Ge Yao, Zelong Zhang, Jianwei Wang
DOI: 10.1039/C7CP02846F
Structural relaxation, viscosity, and network connectivity in a hydrogen bonding liquid
Georg Ehlers, Joerg C. Neuefeind, Souleymane O. Diallo, Christopher B. Stanley, Luke Daemen
DOI: 10.1039/C7CP04013J
Two-dimensional pattern formation in ionic liquids confined between graphene walls
Hadrián Montes-Campos, José Manuel Otero-Mato, Trinidad Méndez-Morales, Oscar Cabeza, Luis J. Gallego, Alina Ciach, Luis M. Varela
DOI: 10.1039/C7CP04649A
First-principles investigation of H2S adsorption and dissociation on titanium carbide surfaces
Shiyan Wang, Xilin Zhang, Yanxing Zhang, Jianjun Mao
DOI: 10.1039/C7CP05756C
您可能还喜欢
2-(甲基磺酰基)嘧啶-5-胺(CAS号:56621-92-2)适用哪些法规指南?
该化合物适用的法规指南包括GHS(全球化学品统一分类和标签制度)分类为特定目标器官毒性-单次接触类别3;根据欧盟REACH法规,该化合物需要进行注册和评估;在美...
在合成中是否有4-(4-氯苯基)-1H-咪唑(CAS号:35512-29-9)的替代品?
在合成中,可以考虑使用一些类似的化合物作为4-(4-氯苯基)-1H-咪唑的替代品,如4-(4-溴苯基)-1H-咪唑或4-(4-甲氧基苯基)-1H-咪唑。这些化合...
什么是N~2~-甲基丙氨酸酰胺(CAS号:32012-16-1)?
N~2~-甲基丙氨酸酰胺是一种有机化合物,其化学名为2-(Methylamino)propanamide。它是一种酰胺类化合物,分子式为C4H10N2O,相对分...
如何处理含有N-苄基-3-氨基氧杂环丁烷草酸盐(CAS号:1956341-96-0)的废料?
处理含有N-苄基-3-氨基氧杂环丁烷草酸盐(CAS号:1956341-96-0)的废料时,应首先确保遵循相关法规要求,如GHS和REACH等。通常,废液应先进行...
4-bromo-2-chloro-6-methylbenzoic acid(CAS号:877149-07-0)的物理化学性质是什么?
4-溴-2-氯-6-甲基苯甲酸是一种固体化合物,具有较高的熔点和较低的沸点。它的分子量为261.03 g/mol。该化合物在水中几乎不溶,在有机溶剂中溶解度适中...
2-[(2,5-二氯-4-嘧啶)氨基]-N-甲基苯甲酰胺(CAS号:761440-08-8)通常如何合成?
该化合物通常通过缩合反应合成,典型的方法是将2,5-二氯嘧啶与N-甲基苯甲酰胺在碱性条件下进行偶联反应。常用的碱包括NaH、LDA等强碱。该合成路线具有较高的选...
在合成中是否有3,5-二溴-4-甲基苯胺(CAS号:13194-73-5)的替代品?
3,5-二溴-4-甲基苯胺在某些合成路线中可能没有直接替代品。然而,在某些应用场景下,可以考虑使用其他类似结构的化合物如3,5-二溴-4-硝基苯胺或3,5-二碘...
2-氯喹啉-4-羧酸甲酯(CAS号:62482-26-2)的主要用途是什么?
2-氯喹啉-4-羧酸甲酯主要用于有机合成和药物合成领域,作为中间体或原料。它在合成某些药物和染料时具有重要作用。此外,该化合物还可能用于某些特定的化学研究中。
i>]吡啶(CAS号:474708-88-8)安全吗?
6-溴-8-氯咪唑[1,2-a]吡啶在操作过程中需要谨慎以确保安全。该化合物具有一定的毒性,吸入其蒸气或粉尘可能导致呼吸道刺激。处理时应佩戴适当的防护装备,如手...
来源期刊
Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.




![5-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)-2H-pyrazolo[3,4-c]pyridazin-3-amine structure 5-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)-2H-pyrazolo[3,4-c]pyridazin-3-amine structure](https://cnstatic.chemtradehub.com/structs/865/865362-74-9-0091.webp)