Investigating the influence of solvent quality on RAFT-mediated PISA of sulfonate-functional diblock copolymer nanoparticles

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发布日期 2020-02-04

DOI 10.1039/C9PY01912J

影响因子 5.582

作者

Shang-Pin Wen, Jack G. Saunders, Lee A. Fielding

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摘要

Polymerisation-induced self-assembly (PISA) has become widely recognised as a versatile and efficient strategy to prepare well-defined diblock copolymer nanoparticles in a range of solvents. In this article, we report the synthesis of anionic, sterically-stabilised, sulfonate-functional diblock copolymer nanoparticles via PISA using a reversible addition–fragmentation chain-transfer (RAFT) polymerisation formulation. Anionic poly(potassium 3-sulfopropyl methacrylate) (PKSPMA) macromolecular chain-transfer agents (macro-CTAs) were synthesised via RAFT solution polymerisation followed by chain-extension with benzyl methacrylate (BzMA) in alcohol/water mixtures to form PKSPMA–PBzMA nanoparticles. The influence of solvent quality on the formation of these nanoparticles was investigated by judiciously changing the alcohol/water ratio, the alcohol co-solvent (ethanol or methanol) and relative copolymer composition. The resulting diblock copolymer nanoparticles were analysed by dynamic light scattering (DLS), transmission electron microscopy (TEM), small-angle X-ray scattering (SAXS), and aqueous electrophoresis. The results demonstrated that nanoparticles with controllable diameters for a fixed copolymer composition can be prepared by altering the co-solvent composition. More specifically, when using different ratios of ethanol/water or methanol/water, the nanoparticle diameter can be tuned from approximately 20 to 200 nm with fixed copolymer composition. This indicates that the solvency of both the stabiliser and core-forming block has a marked impact on both the aggregation of polymer chains during self-assembly and the resulting nanoparticles. Additionally, these nanoparticles remain colloidally stable and highly anionic over a wide pH range from 4 to 10, as judged by aqueous electrophoresis.

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Acta Metallurgica Sinica-English Letters

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Journal of Asian Natural Products Research

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来源期刊

Polymer Chemistry

CiteScore: 8.6

自引率: 7.3%

年发文量: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Investigating the influence of solvent quality on RAFT-mediated PISA of sulfonate-functional diblock copolymer nanoparticles

文献信息

期刊推荐

相关文献

Studies on the affinity of 6-[(n-(cyclo)aminoalkyl)oxy]-4H-chromen-4-ones for sigma 1/2 receptors

Human carboxylesterases and fluorescent probes to image their activity in live cells

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Contents list

Contents list

Design, synthesis, and biological evaluation of pyrazole-linked aloe emodin derivatives as potential anticancer agents‡

Inside front cover

The role of small molecules in cell and gene therapy

Target 2035 – update on the quest for a probe for every protein

Optimization of brain-penetrant picolinamide derived leucine-rich repeat kinase 2 (LRRK2) inhibitors

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