Copper-catalyzed direct couplings of terminal alkynes with primary and secondary benzyl bromides

文献信息

发布日期 2019-04-19

DOI 10.1039/C9QO00335E

影响因子 5.281

作者

Huiru Zhang, Nan Sun, Baoxiang Hu, Zhenlu Shen, Xinquan Hu

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摘要

We have developed a facile Cu-catalyzed benzylation of terminal alkynes from easily available benzyl bromides. Both primary and secondary benzylic bromides have been successfully coupled with various aryl alkynes, alkyl alkynes and enynes, selectively affording benzyl alkynes in moderate to excellent yields. Examples of scale-up reactions as well as the application for preparing substituted allenes and phenanthrene have further demonstrated the practicality and efficiency of the developed strategy.

期刊推荐

Journal of Asian Natural Products Research

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Bioorganic & Medicinal Chemistry Letters

Bioorganic & Medicinal Chemistry

Journal of the Indian Institute of Science

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Critical Reviews in Solid State and Materials Sciences

Colloid Journal

Main Group Chemistry

Topics in Catalysis

来源期刊

Organic Chemistry Frontiers

CiteScore: 7.8

自引率: 8.7%

年发文量: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Copper-catalyzed direct couplings of terminal alkynes with primary and secondary benzyl bromides

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