1,3-Dipolar cycloaddition of nitrones to oxa(aza)bicyclic alkenes
文献信息
发布日期
2019-08-15
DOI
10.1039/C9QO00660E
影响因子
5.281
作者
Yongqi Yao, Wen Yang, Qifu Lin, Weitao Yang, Huanyong Li, Lin Wang, Fenglong Gu, Dingqiao Yang
查看原文
摘要
A new 1,3-dipolar cycloaddition of oxa(aza)bicyclic alkenes with nitrones has been developed. The operationally simple cycloaddition allows efficient synthesis of fused bicyclic tetrahydroisoxazoles bearing exo- and anti-five member heterocyclic rings (76–99% yields) without any catalyst and additive under mild conditions. The proposed concerted mechanism and the observed selectivity are investigated by DFT calculations of the reaction pathways. This mild and practical [3 + 2] cycloaddition provides an efficient route to access highly functionalized compounds.
期刊推荐
Chemical Communications
Current Opinion in Colloid & Interface Science
Current Opinion in Solid State & Materials Science
Russian Journal of General Chemistry
Russian Journal of Applied Chemistry
Crystallography Reports
Nature Medicine
Drug Discovery Today
Russian Chemical Bulletin
Russian Journal of Bioorganic Chemistry
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来源期刊
Organic Chemistry Frontiers
CiteScore:
7.8
自引率:
8.7%
年发文量:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
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