Hybrid isoquinolines from Thalictrum foetidum: a new type of aporphine inhibiting Staphylococcus aureus by combined mechanisms
文献信息
发布日期
2019-08-29
DOI
10.1039/C9QO00737G
影响因子
5.281
作者
Rong-Ping Zhang, Jing Yang, Xu-Jie Qin, Zhi Dai, Ya-Ping Liu, Qiu-Min Lu, Ren Lai
查看原文
摘要
Thalfoetines A–D (1–4), unique hybrid aporphine alkaloids with a C-7 aromatic unit formed by a new C–C bond linking two building blocks, were isolated from Thalictrum foetidum. Their structures were elucidated by extensive spectroscopic and computational analysis. They inhibited bacteria significantly, and compound 1 damaged the cell structure of Staphylococcus aureus and inhibited its DNA synthesis.
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来源期刊
Organic Chemistry Frontiers
CiteScore:
7.8
自引率:
8.7%
年发文量:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
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