DMF/NaOH/H2O: a metal-free system for efficient and chemoselective reduction of α-ketoamides

文献信息

发布日期 2019-09-04

DOI 10.1039/C9QO00842J

影响因子 5.281

作者

Rongcong Ye, Feiyue Hao, Guyue Liu, Qingsong Zuo, Lijun Deng, Zhengneng Jin, Jiashou Wu

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摘要

We have developed a transition metal free method for efficient and chemoselective reduction of CO bonds using DMF as a hydrogen source and solvent. α-Ketoamides bearing various functional groups are smoothly reduced to α-hydroxyamides in high yields with the present DMF/NaOH/H2O reduction system.

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来源期刊

Organic Chemistry Frontiers

CiteScore: 7.8

自引率: 8.7%

年发文量: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

DMF/NaOH/H2O: a metal-free system for efficient and chemoselective reduction of α-ketoamides

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