![5-Bromo-3-isopropyl-1H-pyrrolo[2,3-b]pyridine structure](https://cnstatic.chemtradehub.com/structs/125/1256819-54-1-8620.webp "5-Bromo-3-isopropyl-1H-pyrrolo[2,3-b]pyridine structure")
Oxidant-controlled divergent transformations of 3-aminoindazoles for the synthesis of pyrimido[1,2-b]-indazoles and aromatic nitrile-derived dithioacetals
文献信息
发布日期
2019-08-09
DOI
10.1039/C9QO00847K
影响因子
5.281
作者
Yao Zhou, Yixian Lou, Ya Wang
查看原文
摘要
The oxidant-controlled divergent reactivity of 3-aminoindazoles is presented herein. Diverse functionalized pyrimido[1,2-b]-indazole derivatives were obtained with good yields via a Lewis-acid promoted [3 + 3] annulation reaction between ketene dithioacetals and 3-aminoindazoles. When the reaction was performed using the Cu/[O] catalytic system, new reactivity for the ring-opening of 3-aminoindazoles via C–N bond activation was achieved, which enables the olefinic C–H arylation of ketene dithioacetals under mild conditions.
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Saudi Pharmaceutical Journal
Chemical Communications
Russian Journal of Organic Chemistry
Crystallography Reports
Russian Chemical Bulletin
Current Opinion in Colloid & Interface Science
Russian Journal of Applied Chemistry
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Journal of Saudi Chemical Society
New Journal of Chemistry
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来源期刊
Organic Chemistry Frontiers
CiteScore:
7.8
自引率:
8.7%
年发文量:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
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